Absorbable orthopedic instrument material capable of prompting growth of bone tissues and preparation method thereof

Abstract

The invention discloses an absorbable orthopedic instrument material capable of prompting growth of bone tissues and a preparation method thereof. The material is prepared by compounding a medical absorbable high-molecular polymer, a degradable pure magnesium or magnesium alloy which is loaded with BaTiO3 piezoelectric ceramics, can conduct piezoelectric signals and serves as a conductive carrier material, and grapheme for improving the electric polarization effect. When the absorbable orthopedic instrument material is in use, an electric signal produced by the piezoelectric ceramics under the action of an external load can be effectively conducted to organism tissues around an orthopedic instrument by the conductive carrier material to stimulate the growth of early hard tissues at a bone injury position and promote healing of the bone tissues. The BaTiO3 piezoelectric ceramics is loaded on the conductive carrier material through a dual loading technology consisting of electrophoresis-micro-arc oxidation and sol sealing, coating and film forming. Meanwhile, the conductive carrier material and the grapheme can also enhance the polarization effect and stress sensitivity of the piezoelectric ceramics. A bar material or a plate material is prepared firstly by means of a thermal die pressing, extruding or pulling method, and the orthopedic instrument is made by means of polarization and machining.

Description

Technical field

[0001] The invention relates to an absorbable orthopedic instrument with special functions and a preparation method thereof. During use, a piezoelectric signal that promotes fracture healing and bone tissue growth can be formed. It belongs to the technical field of orthopedic instruments, and is specifically an absorbable bone tissue growth-promoting Orthopedic equipment and its preparation method. Background technique

[0002] In recent years, absorbable bone nails, bone plates and other orthopedic internal fixation devices made of biodegradable polymer materials such as polylactic acid and polyglycolic acid have received more and more attention due to their degradability and low stress shielding effect. . However, when used as orthopedic devices, they also have problems such as weak X-ray absorption and poor imaging effects. At the same time, they cannot generate electrical signals that can stimulate bone tissue growth.

[0003] As everyone knows, fracture heali...

Examples

Embodiment 1

[0029] The selected biodegradable polymer is polylactic acid PLLA, and pure magnesium wire is used as the load BaTiO 3 The carrier and conductor of the piezoelectric ceramic functional film, the volume fraction is 25%, the preparation process is as follows:

[0030] 1) Drawing pure magnesium into wire with a diameter of 0.3mm;

[0031] 2) Preparation of BaTiO 3 Sol solution and electrophoresis-micro arc oxidation treatment: Weigh 0.25 mol of Ba(OH) at room temperature 2 ·8H 2 O dissolved in 170ml of CH 3 In COOH, heat to 70°C and stir vigorously, while cooling and refluxing for 1h, cooling to room temperature, measure 85ml of tetrabutyl titanate, add 250ml of absolute ethanol, quickly stir and cool, add dropwise to the cooling reflux solution, at the same time Stir vigorously for 20 minutes to obtain BaTiO 3 Sol solution. Measure 200mL of colloidal solution and add it to 4L of micro-arc oxidation electrolyte. The main components of the electrolyte are 10g / L sodium silicate, 2g / L Na...

Embodiment 2

[0035] The degradable and absorbing polymer is selected as the copolymer of polylactic acid and polyglycolic acid, PGLA, and AZ31B magnesium alloy sheet is used as the supporting BaTiO 3 The carrier and conductor of the piezoelectric ceramic film have a volume fraction of 40%. The preparation process is as follows:

[0036] 1) Hot-rolled magnesium alloy into 0.5mm plate;

[0037] 2) Preparation of BaTiO 3 Sol solution and electrophoresis-micro-arc oxidation treatment: weigh 0.25mol Ba(OH) at room temperature 2 ·8H 2 O dissolved in 200mL of CH 3 In COOH, heat to 70℃ and stir vigorously, while cooling and refluxing for 2h, cooling to room temperature, measure 85ml of tetrabutyl titanate, add 250ml of absolute ethanol, quickly stir and cool, add dropwise to the reflux solution, at the same time Stir vigorously for 30 minutes to obtain BaTiO 3 Sol solution. Measure 200mL of colloidal solution and add it to 5L of micro-arc oxidation electrolyte. The main components of the electrolyte ar...

Embodiment 3

[0041] The selected degradable and absorbent polymer is polyglycolic acid (PGA), and QE22 magnesium alloy wire is used as the supporting BaTiO 3 The carrier and conductor of the piezoelectric ceramic functional film, the volume fraction is 30%, the preparation process is as follows:

[0042] 1) The magnesium alloy is drawn into a wire with a diameter of 0.5mm;

[0043] 2) Preparation of BaTiO 3 Sol solution and electrophoresis-micro-arc oxidation treatment: weigh 0.25 mol Ba(OH) at room temperature 2 ·8H 2 O dissolved in 200mL of CH 3 In COOH, heat to 70°C and stir vigorously, while refluxing for 2h, cooling to room temperature, measure 100ml of tetrabutyl titanate, add 300ml of absolute ethanol, quickly stir and cool, add dropwise to the refluxing solution, at the same time Stir vigorously for 30 minutes to obtain BaTiO 3 Sol solution. Measure 300mL colloidal solution and add it to 5L micro-arc oxidation electrolyte. The electrolyte components are mainly 10g / L sodium silicate, 3g / ...

Technical field

[0001] The invention relates to an absorbable orthopedic instrument with special functions and a preparation method thereof. During use, a piezoelectric signal that promotes fracture healing and bone tissue growth can be formed. It belongs to the technical field of orthopedic instruments, and is specifically an absorbable bone tissue growth-promoting Orthopedic equipment and its preparation method. Background technique

[0002] In recent years, absorbable bone nails, bone plates and other orthopedic internal fixation devices made of biodegradable polymer materials such as polylactic acid and polyglycolic acid have received more and more attention due to their degradability and low stress shielding effect. . However, when used as orthopedic devices, they also have problems such as weak X-ray absorption and poor imaging effects. At the same time, they cannot generate electrical signals that can stimulate bone tissue growth.

[0003] As everyone knows, fracture heali...

Examples

Embodiment 1

[0029] The selected biodegradable polymer is polylactic acid PLLA, and pure magnesium wire is used as the load BaTiO 3 The carrier and conductor of the piezoelectric ceramic functional film, the volume fraction is 25%, the preparation process is as follows:

[0030] 1) Drawing pure magnesium into wire with a diameter of 0.3mm;

[0031] 2) Preparation of BaTiO 3 Sol solution and electrophoresis-micro arc oxidation treatment: Weigh 0.25 mol of Ba(OH) at room temperature 2 ·8H 2 O dissolved in 170ml of CH 3 In COOH, heat to 70°C and stir vigorously, while cooling and refluxing for 1h, cooling to room temperature, measure 85ml of tetrabutyl titanate, add 250ml of absolute ethanol, quickly stir and cool, add dropwise to the cooling reflux solution, at the same time Stir vigorously for 20 minutes to obtain BaTiO 3 Sol solution. Measure 200mL of colloidal solution and add it to 4L of micro-arc oxidation electrolyte. The main components of the electrolyte are 10g / L sodium silicate, 2g / L Na...

Embodiment 2

[0035] The degradable and absorbing polymer is selected as the copolymer of polylactic acid and polyglycolic acid, PGLA, and AZ31B magnesium alloy sheet is used as the supporting BaTiO 3 The carrier and conductor of the piezoelectric ceramic film have a volume fraction of 40%. The preparation process is as follows:

[0036] 1) Hot-rolled magnesium alloy into 0.5mm plate;

[0037] 2) Preparation of BaTiO 3 Sol solution and electrophoresis-micro-arc oxidation treatment: weigh 0.25mol Ba(OH) at room temperature 2 ·8H 2 O dissolved in 200mL of CH 3 In COOH, heat to 70℃ and stir vigorously, while cooling and refluxing for 2h, cooling to room temperature, measure 85ml of tetrabutyl titanate, add 250ml of absolute ethanol, quickly stir and cool, add dropwise to the reflux solution, at the same time Stir vigorously for 30 minutes to obtain BaTiO 3 Sol solution. Measure 200mL of colloidal solution and add it to 5L of micro-arc oxidation electrolyte. The main components of the electrolyte ar...

Embodiment 3

[0041] The selected degradable and absorbent polymer is polyglycolic acid (PGA), and QE22 magnesium alloy wire is used as the supporting BaTiO 3 The carrier and conductor of the piezoelectric ceramic functional film, the volume fraction is 30%, the preparation process is as follows:

[0042] 1) The magnesium alloy is drawn into a wire with a diameter of 0.5mm;

[0043] 2) Preparation of BaTiO 3 Sol solution and electrophoresis-micro-arc oxidation treatment: weigh 0.25 mol Ba(OH) at room temperature 2 ·8H 2 O dissolved in 200mL of CH 3 In COOH, heat to 70°C and stir vigorously, while refluxing for 2h, cooling to room temperature, measure 100ml of tetrabutyl titanate, add 300ml of absolute ethanol, quickly stir and cool, add dropwise to the refluxing solution, at the same time Stir vigorously for 30 minutes to obtain BaTiO 3 Sol solution. Measure 300mL colloidal solution and add it to 5L micro-arc oxidation electrolyte. The electrolyte components are mainly 10g / L sodium silicate, 3g / ...