Medical dressing and preparation method thereof

A composite cross-linking agent and sodium alginate technology, which is applied in the field of medical materials, can solve problems affecting large-scale production of products, unsatisfactory product stability, and long production cycle, so as to achieve improved stability, shortened cross-linking time, and improved effect of effect

CN105107009AInactive Publication Date: 2015-12-02JIANGSU LANWAN BIOTECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
Publication Date
2015-12-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a medical dressing and a preparation method thereof. The medical dressing comprises a bacterial cellulose membrane, water-soluble chitosan, sodium alginate, hydroxyethyl methacrylate and a compound cross-linking agent. The preparation method comprises the following steps: adding sodium alginate into deionized water; heating, stirring and uniformly mixing; then adding water-soluble chitosan; stirring for dissolution; adding the bacterial cellulose membrane; heating till reaction is finished; then adding the compound cross-linking agent to obtain the medical dressing after cross-linking reaction. Through adoption of the preparation method, the preparation efficiency is improved, and the prepared medical dressing has favorable hemostasis and wound surface healing promotion performance.
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Description

technical field

[0001] The invention belongs to the field of medical materials, and in particular relates to a medical dressing and a preparation method thereof. Background technique

[0002] Bacterial cellulose (BC), also known as microbial cellulose, is a polymer material with a unique nanostructure and excellent comprehensive properties. Due to its unique structure and better mechanical properties than plant cellulose, BC is expected to be used in many fields, such as tissue engineering and biomedical materials, optoelectronic materials, fuel cells, sewage treatment, food industry, paper industry and military industry, etc. Wait. BC fiber diameter is 20-100nm, and the single fiber length is very long. Therefore, BC has a high surface area per unit mass. This characteristic, together with its high hydrophilicity, is an important reason for BC's high water holding capacity. In addition, good biocompatibility makes it an attractive candidate material for a wide range of ...

Examples

Embodiment 1

[0017] A kind of medical dressing, comprises bacterial cellulose film 200g, water-soluble chitosan 20g, sodium alginate 6g, polyhydroxyethyl methacrylate 2g and composite cross-linking agent 3g; Composite cross-linking agent is 25g methacrylic acid- 2-Hydroxyethyl ester and 10g of 2-ethyl-4-methylimidazole were heated to 50°C under the protection of ammonia gas, reacted for 40 minutes, cooled to room temperature, added 10g of lauroyl peroxide, and then heated at a pressure of 0.01MPa Heated to 60°C under negative pressure conditions, stirred and reacted for 20 minutes to obtain a composite crosslinking agent.

[0018] The preparation method of above-mentioned medical dressing, comprises the following steps:

[0019] Step 1: Add sodium alginate into 480g of deionized water, heat to 50°C, stir and mix evenly to obtain mixed solution 1;

[0020] Step 2: Add water-soluble chitosan and polyhydroxyethyl methacrylate to the mixed solution 1, stir to dissolve, add bacterial cellulose...

Embodiment 2

[0023] A medical dressing, comprising bacterial cellulose membrane 300g, water-soluble chitosan 40g, sodium alginate 12g, polyhydroxyethyl methacrylate 5g and composite crosslinking agent 6g; Composite crosslinking agent is the 15g methacrylic acid- 2-Hydroxyethyl ester and 12g of 2-ethyl-4-methylimidazole were heated to 53°C under the protection of ammonia gas, reacted for 46 minutes, cooled to room temperature, added 8g of lauroyl peroxide, and then heated at a pressure of 0.02MPa Heated to 63°C under negative pressure conditions, stirred and reacted for 25 minutes to obtain a composite crosslinking agent.

[0024] The preparation method of above-mentioned medical dressing, comprises the following steps:

[0025] Step 1: Add sodium alginate into 1000g of deionized water, heat to 55°C, stir and mix evenly to obtain mixed solution 1;

[0026] Step 2, adding water-soluble chitosan and polyhydroxyethyl methacrylate to the mixed solution 1, stirring to dissolve, adding bacterial...

Embodiment 3

[0029] A kind of medical dressing, comprises bacterial cellulose membrane 200g, water-soluble chitosan 40g, sodium alginate 12g, polyhydroxyethyl methacrylate 3g and composite cross-linking agent 4g; Composite cross-linking agent is 45g methacrylic acid- 2-Hydroxyethyl ester and 30g of 2-ethyl-4-methylimidazole were heated to 56°C under the protection of ammonia gas, reacted for 55 minutes, cooled to room temperature, added 15g of lauroyl peroxide, and then heated at a pressure of 0.03MPa Heated to 68°C under negative pressure conditions, stirred and reacted for 26 minutes to obtain a composite crosslinking agent.

[0030] The preparation method of above-mentioned medical dressing, comprises the following steps:

[0031] Step 1: Add sodium alginate into 1100g of deionized water, heat to 58°C, stir and mix evenly to obtain mixed solution 1;

[0032] Step 2, adding water-soluble chitosan and polyhydroxyethyl methacrylate to the mixed solution 1, stirring to dissolve, adding bac...