The present invention relates to a
spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no
cholesterol crystals; when reconstituted, the number of large
particulates is reduced; has low
residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under
refrigeration, at
room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits
recovery of the most fragile of proteins, including
von Willebrand's factor; when reconstituted with
Sterile Water for Injection (SWFI), reconstituted
plasma is at a pH that is near normal
plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).