53 results about "Triglyceride synthesis" patented technology

The present invention provides a novel method for inhibiting sugar-induced weight gain resulting from fructose and glucose driven lipogenesis. The method for inhibiting sugar-induced weight gain is comprised of administering a composition comprising a mixture of Free-B-Ring flavonoids and flavans synthesized and / or isolated from a single plant or multiple plants, preferably in the Scutellaria and Acacia genus of plants to a host in need thereof. The present also includes novel methods for the prevention and treatment of diseases and conditions resulting from high carbohydrate ingestion. The method for preventing and treating these sugar-induced diseases and conditions is comprised of administering to a host in need thereof a therapeutically effective amount of a composition comprising a mixture of Free-B-Ring flavonoids and flavans synthesized and / or isolated from a single plant or multiple plants, preferably in the Scutellaria and Acacia genus of plants and a pharmaceutically acceptable carrier.

The invention discloses a high-fiber sugarless bean dreg biscuit and a processing method thereof. The invention is characterized in that the bean dreg biscuit is prepared from the following raw materials in portions by weight: 100 portions of flour, 40-60 portions of dry bean dreg powder, 40 portions of corn starch, 25 portions of water, 16 portions of edible vegetable oil, 10 portions of egg, proper amount of swelling agent, proper amount of edible salt and proper amount of flavor. By fully utilizing the abundant proteins and celluloses and low fat content of the bean dregs, the invention can decelerate the absorption of the excess sugar by human bodies, eliminate the hunger sensation and inhibit the lipogenesis, thereby achieving the effect of losing weight.

The present invention relates to methods and compositions for modulating lipogenesis, lipid accumulation and lipid metabolism in a cell. These methods and compositions modulate genes which are controlled by LXRα, including the lipogenic transcription factor SREBP-1c.

Biomarkers relating to de novo lipogenesis are provided, as well as methods for using such biomarkers in an Index to assess DNL. In addition, methods for diagnosing, determining predisposition to, and monitoring progression / regression of diseases related to DNL are provided. Also provided are methods of monitoring the efficacy of treatments for diseases related to DNL as well as other methods based on biomarkers of DNL.

Methods of culturing sebocyte cells, isolated populations of sebocytes, and methods of using the cultured sebocyte cells for screening compounds that inhibit or activate lipogenesis are provided.

Optical methods and devices are provided for the reduction of the lipid content of adipocytes without significant heat or intolerable adverse effect on the cells and their surrounding tissues. The optical method and device can be used to irradiate adipose tissue through the skin with non-thermal and non-destructive effects by application of near infrared (NIR) irradiation at selected wave bands in selected ranges to affect modulation of innate enzymatic processes involved in lipolysis, lipogenesis, leptin secretion, adiponectin secretion, and / or glucose absorption.

The invention discloses a low fat chicken raising method, which comprises controlling growth velocity, and controlling lipogenesis through shortening feed time, wherein only plant fodder formulation is employed, and animal fat and feed stuff are strictly prohibited. By adopting different fodder formulation based on the physiological requirements of various growth phases of the chickens, the lipogenesis can be regulated and controlled.

The present invention is related to an extract of Cucurbitaceae family plant or the purified extract isolated therefrom having anti-adipogenic and anti-obesity activity, and a composition comprising the same. The extract of Cucurbitaceae family plant of the present invention showed potent reducing activity of body weight, decreasing effect on the blood triglyceride and cholesterol level, activating activity of PPAR α and δ, reducing activity of the gene expression of stearoyl-CoA desaturase, and preventing activity from the adipogenesis of precursor fat cells with no toxicity, therefore, those extract can be useful in treating or preventing obesity and adipogenesis-involved diseases as a medicine or health care food.

Methods of culturing sebocyte cells, isolated populations of sebocytes, and methods of using the cultured sebocyte cells for screening compounds that inhibit or activate lipogenesis are provided.

A peptide formed from the amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2 shows a melanogenesis increment activity and an adipogenesis inhibitory activity. The peptide, by increasing phosphorylation of MITF, which is a transcription factor for increasing a tyrosinase expression, and CREB for increasing an MITF expression, consequently increases a tyrosinase expression and ultimately increases melanin synthesis. The peptide, by reducing the amount of fat accumulated inside a cell and reducing expressions of perilipin and PPARγ, which contribute to adipogenic mechanism, ultimately inhibits adipogenesis. A composition for remedying or treating melanin hypopigmentation, a composition comprising the peptide, and a pharmaceutical composition for treating or preventing obesity, are provided.

The present invention relates to Cucurbitaceae plant extracts or purified extracts isolated therefrom having anti-adipogenic and anti-obesity activities, and compositions comprising them. Cucurbitaceae plant extract of the present invention exhibits effective body weight-lowering activity, lowering blood triglyceride and cholesterol content, activating PPARα and δ activity, reducing stearoyl-CoA dehydrogenase gene expression activity and preventing preadipocytes Adipogenesis activity, and no toxicity, therefore, those extracts can be used as medicine or health food for the treatment or prevention of obesity and diseases involving adipogenesis.

The invention discloses novel stilbene compound oligomers in sword iris (Iris lacteal Pall .var .chinensis(Fisch .)Koidz .) seed kernels as well as an extraction method and usage thereof. The extraction method of the novel stilbene compound oligomers in the sword iris seed kernels comprises the following steps: performing amplified preparation on an alkali extracted and acid precipitated product of sword iris seed kernels; and then, carrying out two times of preparation by adopting an aqueous cetonitrile solution as mobile phase so as to obtain the novel stilbene compound oligomers S11 in thesword iris seed kernels, namely VitisinA-13b-o-glucoside. The invention further provides application of the new compound S11 in preparation of medicines used for preventing and / or treating lipid metabolism disorder. And moreover, inhibition of cell lipogenic differentiation and lipogenesis by the novel stilbene compound oligomers S11 is verified by studying activity of the novel stilbene compoundoligomers S11; so that, the novel stilbene compound oligomers S11 can be used for preparing medicines which are capable of preventing or treating metabolic disorders, such as obesity, hyperlipidemia and the like.

The present invention provides a compound comprising a helminth-derived glycan and / or glycoconjugate thereof (e.g., a compound comprising a Lewisx antigen (e.g., LNFPIII), a non-Lewisx antigen (e.g., LNnT, LDN, and LDN derivatives), or a mixture of Lewisx and non-Lewisx antigens (e.g., SEA)), useful as a therapeutic compound for treating or preventing diseases associated with fat accumulation in the liver. The compounds of the invention are useful for treating or preventing the development of a fatty liver disease in a subject that has the disease or is at risk of developing the disease, and inhibiting lipogenesis in hepatocytes. The invention also provides methods of regulating the Erk-c-fos / AP-1-FXRα signalling pathway by administering a compound comprising a helminth-derived glycan and / or glycoconjugate thereof to a subject with a fatty liver disease, or contacting a hepatocyte with a compound comprising a helminth-derived glycan and / or glycoconjugate thereof.

The invention belongs to the technical field of biology. The invention relates to a gene with a triglyceride synthesis function and a construction method thereof and an application thereof for rationally regulating contents of oil-producing microalgae triglyceride and polyunsaturated fatty acid. The gene is: 1) a base sequence shown as SEQ ID NO: 1 or 2; or 2) a DNA sequence of the protein encoding the same biological function and having 95% or more homology with the nucleic acid sequence defined by a sequence 1 or 2 in a sequence table. The full-length gene and the amino acid sequence as nannochloropsis are firstly reported, and the members of the DGAT gene family can be enriched; overexpression of the above gene can significantly improve the ability of nannochloropsis to synthesize TAG,and the application value in using genetic engineering to improve the production of TAG in organisms can be improved; in addition, overexpression of the above gene can increase the specific PUFA content in the TAG, and therefore the method has the potential to increase the yield of a high value-added compound of microalgae.

This document provides oilseed plants (e.g., pennycress plants) having increased levels of one or more saturated fatty acids, increased levels of one or more polyunsaturated fatty acids (PUFAs), altered (e.g., increased or decreased) levels of oleic acid, and / or altered (e.g., increased or decreased) levels of erucic acid. For example, oilseed plants having reduced polypeptide levels and / or reduced polypeptide activity of one or more polypeptides involved in triglyceride synthesis (e.g., diacylglycerol O-acyltransferase 1 (TAG1) can have increased levels of stearic acid, increased levels of one or more PUFAs, altered levels of oleic acid, and / or altered levels of erucic acid. Also provided herein are methods and materials for making and using oilseed plants having increased levels of one or more saturated fatty acids, increased levels of one or more PUFAs, altered levels of oleic acid, and / or altered levels of erucic acid.

The downregulation of PRP 19 (precursor RNA processing 19) protein expression results in effectively reducing the expression of SCD1 (stearyl CoA desaturase-1), the key lipogenic enzyme, and its down-stream triacylglycerol synthesis enzymes, DGAT-1 (diacyglycerol acyltransferase-1) and GPAT (glycerol-phosphate acyltransferase), as well as the intracellular content of neutral lipids, the major target for treating obesity.

The invention discloses an anti-saccharification moisturizing cream and a preparation method thereof. The cream is prepared from an olive oat emulsifier, cetearyl alcohol, isooctadecyl isooctadecanoate, caprylic acid / capric acid triglyceride, synthetic squalane, polydimethylsiloxane, 2,6-di-tert-butyl-4-methylphenol, disodium EDTA, glycerol, propylene glycol, xanthan gum, carbomer 940, triethanolamine, Inonotus obliquus water extract, Inonotus obliquus alcohol extract, phellinus igniarius alcohol extract, a polysaccharide skin tightening agent, sodium hyaluronate, nicotinamide, panthenol, PCG, water and the like. The product of the invention is an oil-in-water emulsifying system, the novel mild olive oat emulsifier is selected, the Inonotus obliquus water extract and the Inonotus obliquusalcohol extract are used as main anti-saccharification components, and active components such as the phellinus igniarius alcohol extract and the polysaccharide skin tightening agent are compounded, so that the anti-saccharification effect of the product is improved, the effects of moisturizing skins, resisting oxidation, resisting inflammation and the like are enhanced, and the product can make the skin smooth, tender and tight after long-term use and can delay aging. The product of the invention can also be used by people with mild, no irritation and sensitive skin.

The present invention is related to an alcohol compound isolated from the extract of Cucurbitaceae family plant having anti-adipogenic and anti-obesity activity, and a composition comprising the same. The compound showed potent reducing activity of body weight, decreasing effect on the blood triglyceride and cholesterol level, activating activity of PPAR α and preventing activity from the adipogenesis of precursor fat cells with no toxicity, therefore, those extract can be useful in treating or preventing obesity and adipogenesis-involved diseases as a medicine or health care food.

In a composition and a microneedle for a localized obesity treatment containing the same in accordance with the present disclosure, the composition in accordance with the present disclosure contains a gelatin, decomposes a fat in a body, and inhibits lipogenesis and fat deposition in the body.

The invention belongs to the technical field of pharmacy, and relates to an application of a dendrobium nobile water extract in treating type 2 diabetes mellitus, in particular to regulation of insulin resistance and triglyceride synthesis of a dry dendrobium water extract and a fresh dendrobium water extract in a high-sugar state. Experimental results prove that the dendrobium nobile water extract prepared by the invention can obviously inhibit the expression level of mRNA of fatty acid binding protein, improve the peripheral insulin resistance, protect the pancreatic beta cell function, increase insulin sensitivity, obviously inhibit the expression level of diacylglycerol acyltransferase mRNA, reduce the TG biosynthesis, improve the sensitivity of the body to insulin and leptin, increasethe mRNA expression level of sterol regulatory element-binding protein 1, and effectively regulate the triglyceride biosynthesis so as to achieve inhibition of type 2 diabetes mellitus from multipleaspects. Therefore, the dendrobium nobile water extract disclosed by the invention can be used for treating type 2 diabetes mellitus and has a good development prospect in the aspect of treating type2 diabetes mellitus.

The invention relates to a use of glycerol kinase in preparation of a drug for regulating lipid metabolism. The use reveals that glycerol kinase can catalyze glycerol into 3-phosphoglycerol for triglyceride synthesis, control the expression of SREBP-1c to adjust and control hepatic fatty acid and triglyceride synthesis and play an important role in maintenance of the blood lipid homeostasis. The lipid metabolism disorder mouse model has high glycerol kinase expression and thus through inhibiting the expression of glycerol kinase, the drug can significantly improve high fat food-induced fatty liver and hypertriglyceridemia. Therefore, glycerol kinase is a new target for preventing, alleviating or treating fatty liver and hypertriglyceridemia.

The present invention discloses a fat eliminating and health preserving sweet orange drink which is prepared from the following raw materials by weight: 600-650 parts of sweet orange, 50-60 parts of strawberry, 20-25 parts of oats, 8-10 parts of apple enzyme powder, 15-20 parts of wine lees, 3-5 parts of winter collybia stipe dietary fibers and the like. The winter collybia stipe dietary fibers and psyllium shell powder contain soluble dietary fibers which can help human body to expel residues, and linden, chrysanthemum, garcinia pedunculata and the like are matched to achieve effects of slimming and swelling subsiding, and can inhibit lipogenesis to achieve the purpose of fat eliminating.

The present invention provides a method for reducing the expressions of the sterol regulatory element-binding protein 1C (SREBP-1C), acetyl-CoA carboxylase (ACC), and stearoyl-CoA desaturase 1 (SCD-1), comprising administering to a subject a composition comprising an effective amount of a longan pericarp extract. The longan pericarp extract significantly inhibits lipogenesis, reduces the glutamic-pyruvic transaminase (GPT) index, and protects the liver.

The invention discloses an engineered yeast strain producing nervonic acid. The yeast strain overexpresses genes related to enzymes required for the synthesis of long-chain unsaturated fatty acids such as fatty acid elongase, desaturase, and diglyceride acyltransferase, and any Optionally, the triglyceride synthesis and decomposition pathway, the sphingomyelin synthesis and decomposition pathway, the lipid subcellular level synthesis and decomposition pathway, and the redox balance pathway of the strain are further regulated. The recombinant yeast strain can produce microbial oil, and the content of the prepared nervonic acid accounts for 39.6% of the total fatty acid content.

The invention belongs to the technical field of pharmacy, and relates to application of a fresh dendrobe aqueous extract in preparation of drugs for treating metabolic diseases. The invention particularly relates to adjustment of fatty acid and triglyceride synthesis by a fresh dendrobe aqueous extract. Experimental results prove that the fresh dendrobe aqueous extract prepared by the invention can obviously inhibit the mRNA expression level of sterol regulatory element binding protein 1, diacylglycerol acyltransferase and microsome triacylglycerol transporter, and effectively regulate the biosynthesis of triglyceride; and the fresh dendrobe aqueous extract can obviously inhibit the mRNA expression levels of acetyl-CoA carboxylase, fatty acid synthase and stearoyl-CoA desaturase, and effectively regulate fatty acid synthesis; and the fresh dendrobe aqueous extract can inhibit the mRNA expression level of the FABP4, improve the peripheral insulin resistance, protect pancreatic beta cellfunctions, and improve the sensitivity of insulin, thereby inhibiting the metabolic diseases related to the FABP4; and therefore, the fresh dendrobe aqueous extract prepared by the method can be usedas the drug for treating the metabolic diseases.

The invention discloses a skin-soothing cream capable of soothing and repairing sensitive skin, and relates to the technical field of skin-care products. The skin-soothing cream is prepared from the following compound components in percentage by weight: 30 to 50 percent of butyrospermum parkii butter, 20 to 40 percent of triglyceride, 5 to 13 percent of synthetic bee wax, 2 to 6 percent of micro-crystalline wax, 0.1 to 5 percent of simmondsia chinensis seed oil, 0.1 to 5 percent of tocopheryl acetate, 1.2 percent of alkanet root extract / glyceryl acetate, 0.5 percent of bisabolol, 0.001 to 0.5 percent of pelargonium graveolens oil, 0.01 to 5 percent of squalane, 0.01 to 5 percent of Europe juniper fruit oil, 0.01 to 5 percent of argania spinosa kernel oil, 0.01 to 5 percent of camellia oleosa seed oil, 0.01 to 5 percent of sweet almond oil, 0.01 to 5 percent of sunflower seed oil, 0.01 to 5 percent of pentaphyllum camarum seed oil / rosa canina fruit extract, 0.01 to 5 percent of baobab seed oil and 0.001 to 0.5 percent of plum-leaf crab seed oil. According to the skin-soothing cream capable of soothing and repairing the sensitive skin, oil is used for nourishing the skin, the content of unsaturated fatty acid in the skin is increased, and the barrier function of the skin is improved.

The present invention relates to a composition comprising a combination of at least one proteolytic enzyme, such as subtilisin, and at least one lipolytic enzyme, for use in preventing triglyceride synthesis, advantageously by degrading 2-monoacylglycerol in the intestine. The subject matter of the invention is also such a composition for use as a medicament, as a cosmetic agent, as a medical device, as a food composition, as a food supplement or else as a nutriceutical, in particular for use in preventing or treating obesity, atherosclerosis or type II diabetes, or else for use in preventing or reducing excess weight.

Provided in the present invention are adult stem cells derived from human skin dermis, and a method for isolating same. Further provided in the present invention are osteoblastic cells and adipocytes differentiated from the adult stem cells derived from human skin dermis, and a differentiation method therefor. Further provided in the present invention is a composition for osteogenesis or lipogenesis containing the stem cells, osteoblastic cells, or adipocytes. The isolation method of the present invention enables the adult stem cells derived from human skin dermis to be obtained in an easy and simple manner at a high yield rate. Genes and growth factors which are specifically expressed in the adult stem cells derived from human skin dermis isolated using the method can be separated, identified, and used later.