A
system and method for operating automated guided vehicles (AGVs) and autonomous mobile robots are disclosed. The
system for operating AGVs includes: an AGV that loads components in a vehicle manufacturing
plant and transfers the components along a set travel path; a
programmable logic controller (PLC) located on a
production line and at each of a plurality of nodes present on the travel path, and controlling
peripheral automation facilities; and an operation
server configured to control the operation of the AGV and each
automation facility via the PLC, and to set PLC control conditions for controlling each
automation facility in each segment by collecting PLC memory data from the PLC and querying the PLC memory data based on the movement position of the AGV when setting the travel path.