The invention discloses a comprehensive appearance detection device for mechanical flow line production, which comprises a detection base and a detection rotating mechanism, wherein detection installation plates are arranged around the detection base, an appearance detection mechanism is arranged on each detection installation plate, the detection rotating mechanism comprises a rotation base component, a rotation driving component, a rotation transmission component and belt transmission components, the rotation driving component is connected with the rotation transmission component, the rotation transmission component is connected with the belt transmission components, the belt transmission components are connected with belt tensioning components, an appearance detection plate is arranged at the top of each belt transmission component, a detection clamp is arranged on the appearance detection plate and a detection workpiece is arranged in the detection clamp. The device is arranged in the last process of a mechanical flow line, is used for carrying out appearance detection on processed detection workpieces to judge whether the detection workpiece meets the production standard, and has the advantages of eliminating defects of artificial detection, improving the working efficiency of product detection and enhancing the production efficiency and economical benefits of the enterprises.