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44results about How to "Suitable mechanical strength" patented technology

End-capped modified polyethylene glycol cross-linking agent having ultraviolet light response function, preparation method and hydrogel dressing containing cross-linking agent and preparation method thereof

The invention belongs to the technical field of biomedical dressings and relates to an end-capped modified polyethylene glycol cross-linking agent having an ultraviolet light response function, a preparation method and a hydrogel dressing containing the cross-linking agent and a preparation method thereof. The technical problem is solved that wound pain and secondary wounds care caused by when anexisting hydrogel dressing is removed for secondary wound treatment. The modified polyethylene glycol cross-linking agent having the ultraviolet light response function is formed by adopting an injectable in-site gel forming mode, and the gel forming mode has very good adaptability to wound shapes and meanwhile has better fitting property compared with a blocky dressing to be gelled without auxiliary fixing materials. When wounds need to be further treated, regional selective irradiation can be performed through 10 mw/cm<2> ultraviolet light of 365 nm, gel softening and degradation are achieved. Compared with other dressings, the function can prevent wound pain during gel removal and prevent newly growing tissues from being physically harmed to cause secondary wounds.
Owner:CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI

Capped modified polyethylene glycol cross-linking agent with ultraviolet light response function and its preparation method, and hydrogel dressing containing the cross-linking agent and its preparation method

The invention belongs to the technical field of biomedical dressings and relates to an end-capped modified polyethylene glycol cross-linking agent having an ultraviolet light response function, a preparation method and a hydrogel dressing containing the cross-linking agent and a preparation method thereof. The technical problem is solved that wound pain and secondary wounds care caused by when anexisting hydrogel dressing is removed for secondary wound treatment. The modified polyethylene glycol cross-linking agent having the ultraviolet light response function is formed by adopting an injectable in-site gel forming mode, and the gel forming mode has very good adaptability to wound shapes and meanwhile has better fitting property compared with a blocky dressing to be gelled without auxiliary fixing materials. When wounds need to be further treated, regional selective irradiation can be performed through 10 mw / cm<2> ultraviolet light of 365 nm, gel softening and degradation are achieved. Compared with other dressings, the function can prevent wound pain during gel removal and prevent newly growing tissues from being physically harmed to cause secondary wounds.
Owner:CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI

Marine biological medical material for repairing skin wounds as well as preparation method and application of marine biological medical material

The invention discloses a marine biological medical material for repairing skin wounds as well as a preparation method and application of the marine biological medical material. From a plurality of marine bioactive substances, preferably, marine fish skin collagen, carboxymethyl chitosan and alginate which are good in biocompatibility and easy to process and degrade are scientifically combined with platelet-derived growth factors PDGF-BB, and optimization is carried out, so that the marine collagen-based hydrogel is prepared. The material has the advantages of being high in porosity, high in swelling ratio, good in mechanical property, capable of controlling slow release of PDGF-BB, free of cytotoxicity and the like, cell adhesion, proliferation, migration and vascularization can be remarkably promoted, inflammatory response is effectively relieved, and scar hyperplasia is reduced. The biomedical material is wide in application range and convenient to use, can prevent bacterial infection without frequent replacement, and has remarkable effects of promoting regeneration and repair of burns, scalds, cutting wounds, traffic wounds, surgical wounds, war wounds, firearm wounds combined with seawater soaking wounds, diabetic ulcers, inflammatory ulcers, pressure ulcers and chronic refractory wounds.
Owner:SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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