Method for reducing measurement deviation of current type biosensors

A biosensor and sensor technology, applied in biochemical equipment and methods, measurement/inspection of microorganisms, electrochemical variables of materials, etc., can solve problems such as increased power consumption, reduced signal strength, and needs to be improved to achieve accuracy and Accuracy improvement, deduction of interference noise, effect of high signal value

Active Publication Date: 2008-02-20
APEX BIOTECH
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Problems solved by technology

[0007] However, although the continuous power supply method adopted by the former has the effect of reducing the background current, it cannot accumulate the reaction intensity of the analyte to reduce the signal intensity, and also increases power consumption; on the other hand, although the latter adopts a fixed voltage to eliminate the main The method of cutting off the power after background interference to re

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  • Method for reducing measurement deviation of current type biosensors
  • Method for reducing measurement deviation of current type biosensors
  • Method for reducing measurement deviation of current type biosensors

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[0037] Example

[0038] Set 2 sets of power supply mode states, just like the initial supply voltage of 300mV in the prior art (Figure 1-1), and immediately power off to 0mV after the sample is added to the electrode system; the other is the concept of the present invention (Figure 2- 2) The initial supply voltage is 300mV. After the sample is added to the electrode system, the supply voltage is gradually reduced to 0mV after 4 seconds (the electrochemical oxidation-reduction reaction is interrupted).

[0039]With the aforementioned two set power supply modes, for the same batch of glucose biosensor test pieces after accelerated aging, containing blood with different concentrations of glucose at low, medium and high at the same time, after reacting for 16 seconds, apply a driving voltage of 300mV, and The redox current positively correlated with the glucose concentration was measured, and the result is shown in Figure 3.

[0040] When using the conventional power supply mode for t...

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Abstract

The invention relates to a method for measuring the contents in the sample to be measured, which comprises the following steps: (a) combining a voltaic biosensor which includes at least one electrode assembly and oxidation-reduction electric agent, and exerts one preset voltage on the electrode assembly; (b) putting a sample in the biosensor and immediately setting the preset voltage value down gradually until it cannot drive the electric agent to oxidation-reduction react;(c) after reacting enough time, providing a second voltage on the electrode assembly which can drive the electric agent to react;(d) measuring the electrochemical reaction current of said electrode assembly, deciding the contents in the sample to be measured.

Description

technical field [0001] The invention relates to a method for reducing the measurement deviation of an amperometric biosensor, which is characterized in that when a test sample is placed into a sensor with a preset voltage to the electrode system, the preset voltage is immediately reduced in the early stage of the biosensor reaction Eliminate background currents of major disturbances. Background technique [0002] The method of using amperometric biosensors to measure specific analytes in liquid test samples is often used in the monitoring of clinical physiological abnormalities, such as enzymatic amperometric blood glucose and lactic acid sensing methods, and non-enzymatic uric acid and heme sensing methods. Whether it is an enzymatic or non-enzymatic system, an electronic mediator is used as an electronic signal transmission medium for the redox reaction of the analyte. [0003] As shown in Figure 1-1, due to the oxidation reaction of the analyte in the test sample, the te...

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Application Information

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IPC IPC(8): G01N27/49C12Q1/00G01N27/48
Inventor 林岳晖黄英哲黄锡彬沈承禹沈燕士
Owner APEX BIOTECH
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