Method for reducing measurement deviation of current type biosensors

Abstract

The invention relates to a method for measuring the contents in the sample to be measured, which comprises the following steps: (a) combining a voltaic biosensor which includes at least one electrode assembly and oxidation-reduction electric agent, and exerts one preset voltage on the electrode assembly; (b) putting a sample in the biosensor and immediately setting the preset voltage value down gradually until it cannot drive the electric agent to oxidation-reduction react;(c) after reacting enough time, providing a second voltage on the electrode assembly which can drive the electric agent to react;(d) measuring the electrochemical reaction current of said electrode assembly, deciding the contents in the sample to be measured.

Description

technical field [0001] The invention relates to a method for reducing the measurement deviation of an amperometric biosensor, which is characterized in that when a test sample is placed into a sensor with a preset voltage to the electrode system, the preset voltage is immediately reduced in the early stage of the biosensor reaction Eliminate background currents of major disturbances. Background technique [0002] The method of using amperometric biosensors to measure specific analytes in liquid test samples is often used in the monitoring of clinical physiological abnormalities, such as enzymatic amperometric blood glucose and lactic acid sensing methods, and non-enzymatic uric acid and heme sensing methods. Whether it is an enzymatic or non-enzymatic system, an electronic mediator is used as an electronic signal transmission medium for the redox reaction of the analyte. [0003] As shown in Figure 1-1, due to the oxidation reaction of the analyte in the test sample, the te...

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Problems solved by technology

[0007] However, although the continuous power supply method adopted by the former has the effect of reducing the background current, it cannot accumulate the reaction intensity of the analyte to reduce the signal intensity, and also increases power consumption; on the other hand, although the latter adopts a fixed voltage to eliminate the main The method of cutting off the power after background interference to reduce power consumption also eliminates the signal converted to the electronic medium by redox at the initial stage after the analyte is placed in the measurement cell, that is, the signal in the early stage of the reaction period cannot be accumulated

Thereby, in the operation method of prior art, the accuracy of Cottrell current and the concentration relation of proxies in the test sample still needs to be improved.

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