Nicorandil freeze-drying powder preparation method

A technology of nicorandil and freeze-dried powder, which is applied in the field of pharmaceutical injection preparation to achieve the effects of ensuring safety, reducing the generation of harmful impurities and improving stability
CN100417381CActive Publication Date: 2008-09-10XIAN LIBANG PHARMA TECH
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Patents(China)
Current Assignee / Owner
XIAN LIBANG PHARMA TECH
Publication Date
2008-09-10

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Abstract

The invention discloses a process for preparing Nicorandil freeze-dried powder, which consists of charging 0.1-50.0 wt% of Nicorandil into water for injection, dissolving excipient simultaneously, degerming and filtering, loading, and finally freeze drying.
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Description

technical field

[0001] The present invention relates to a kind of preparation method of the injection of medicine, especially the preparation method of nicorandil freeze-dried powder, this method uses amino acid substance as excipient, adopts freeze-drying technology to prepare the freeze-dried powder of nicorandil, can be Intravenous injection avoids the degradation of nicorandil into other substances with toxic and side effects in water, and ensures the safety of medication for patients. The product has good resolubility, and it can be used directly after being dissolved in sterile water for injection, normal saline, glucose injection, etc. when used clinically. Background technique

[0002] Nicorandil, also known as Nicotinate and Nicotinate, belongs to nitrate ester compounds, and is the only drug for the treatment of coronary heart disease and angina pectoris with a dual mechanism of action among the currently marketed cardiovascular system drugs. It not only has the e...

Claims

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