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Application of composition for preparing medicine to treat chilblain disease

The technology of a composition and a medicine is applied in the application field of the composition in the preparation of a medicine for treating chilblain diseases, and can solve the problems of treating the symptoms but not the root cause, and cannot fundamentally solve the pain of patients and the like.

Inactive Publication Date: 2008-12-24
GUANGXI HUAHONG PHARMACEUTICAL CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no effective and reliable drug for the treatment of chilblain. Usually, physical therapy, such as hot compress, massage, etc., is used to treat the surface but not the root cause, and cannot fundamentally solve the pain of the patient.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Manufacturing pharmaceutical composition 6000g:

[0036] 1. Raw material composition

[0037] Woody Fragrance 47g Fangfeng 47g Nepeta 47g Asarum 47g

[0038] Wujiapi 47g Guizhi 47g Achyranthes bidentata 47g Chuanxiong 47g

[0039] Xu Changqing 47g Angelica dahurica 70g Curcuma 47g Red Eucommia 70g

[0040] Big Luo Umbrella 100g Xiao Luo Umbrella 70g Double-faced Needle 100g Huangteng 95g

[0041] Gardenia 100g Triangle 70g Agarwood 32.5g Camphor 55g Menthol 55g

[0042] 2. Preparation method:

[0043] The above twenty-one flavors, except camphor and menthol, the other nineteen flavors such as woody fragrance are ground into coarse powder, according to the percolation method (Chinese Pharmacopoeia 2000 edition one appendix 10) under the liquid extract and extract item, use The volume concentration is 53% ethanol as a solvent, after soaking for 28 hours, slowly infiltrate at a speed of about 3ml per minute, collect 5300g of the filtrate, and store it in another conta...

Embodiment 2

[0045] Manufacturing pharmaceutical composition 10000g:

[0046] 1. Raw material composition

[0047] Woody Fragrance 47g Fangfeng 100g Nepeta 47g Asarum 47g

[0048] Wujiapi 100g Guizhi 47g Achyranthes bidentata 47g Chuanxiong 100g

[0049] Xu Changqing 47g Angelica dahurica 70g Curcuma 100g Red Eucommia 70g

[0050] Big Luo Umbrella 100g Xiao Luo Umbrella 70g Double-faced Needle 100g Huangteng 95g

[0051] Gardenia 100g Triangle 100g Agarwood 32.5g Camphor 60g Menthol 65g

[0052] 2. Preparation method:

[0053] The above twenty-one flavors, except camphor and menthol, the other nineteen flavors such as woody fragrance are ground into coarse powder, according to the percolation method (Chinese Pharmacopoeia 2000 edition one appendix 10) under the liquid extract and extract item, use Use 75% ethanol as a solvent, soak for 24 hours, slowly percolate at a rate of about 3ml per minute, collect 9200g of the filtrate, and store it in another container; take camphor, menthol a...

Embodiment 3

[0055] Adopt the tincture of embodiment 1 to carry out pharmacodynamic study:

[0056] 1. Detumescence effect

[0057] There were 6 Japanese white rabbits in each group, and the hair was cut within 8cm from the tip of the ear, and placed in a freezing tank (-18±1°C) for 70 seconds. After 24 hours of freezing, the drug was administered in the freezing place. There were 3 groups of drug administration groups. , each group was given 10ml, 7ml or 5ml for 7 consecutive days. The results showed that, compared with the blank control group, middle and high doses of the tincture of Example 1 significantly reduced the inflammatory reaction of frostbite tissue redness and swelling, and prevented blister generation and tissue necrosis. This suggests that the tincture of embodiment 1 has the tendency of treating frostbite.

[0058] 2. Effects on Perfusion Flow of Isolated Rabbit Ears

[0059] There are 5 Japanese big-eared white rabbits in each group, and the dosage of the tincture of E...

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PUM

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Abstract

An application of the composition composed of 21 Chinese-medicinal materials including aucklandia root, etc in preparing the medicines for treating the chilblain is disclosed. It has high curative effect (94.4-98.9%).

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine composition, in particular to the application of a medicinal composition composed of Chinese medicines such as woody incense in the treatment of chilblains. Background technique [0002] Frostbite refers to that the human body is attacked by cold pathogens, causing stagnation of qi and blood, which causes local or systemic damage. Those who are cold will feel the evil of cold. Those with sores are wounds. [0003] The theory of traditional Chinese medicine believes that chilblain is caused by the invasion of skin and muscles by severe cold, and the stagnation of qi and blood due to poor circulation of qi and blood. Usually, the weakness of qi and blood or excessive fatigue, extreme cold and heat, and extreme heat and freezing can also cause this disease. Therefore, the clinical treatment of traditional Chinese medicine is mainly based on warming the meridians and expelling c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K36/902A61K36/835A61K36/758A61K36/744A61K36/59A61K36/54A61K36/538A61K36/285A61P17/02
Inventor 韦飞燕
Owner GUANGXI HUAHONG PHARMACEUTICAL CO LTD