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Hemostatic micro-granules and its prepn. method

A particle and microporous technology, which is applied in the field of medical hemostatic particles and its preparation, can solve problems such as insecurity, and achieve the effect of promoting blood clot formation and good biocompatibility

Active Publication Date: 2009-01-21
HANGZHOU SINGCLEAN MEDICAL PROD
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  • Summary
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  • Application Information

AI Technical Summary

Problems solved by technology

However, its medicinal ingredients are mainly bovine thrombin extracted from animals, which is not safe

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1) Preparation of starch solution:

[0022] Accurately weigh 4.0 g of edible potato (potato) starch with an electronic balance, measure 40 to 200 ml of distilled water with a graduated cylinder, and mix evenly in a 250 ml beaker;

[0023] Add 1 mol / L NaOH solution dropwise to the above starch solution, and observe with pH test paper until the pH of the solution is within the range of 8.0 to 10.0;

[0024] 2) Preparation of paraffin oil-starch mixed solution:

[0025] The above-mentioned starch solution with adjusted pH value is emulsified with span80 and dispersed with paraffin oil, that is, accurately take 0.4-10.0g of span80 emulsifier with an electronic balance, and measure 100-1200ml of liquid paraffin with a measuring cylinder, add it to a grinding-mouth flask, install and stir Put the ground flask in a constant temperature water bath at 50-70°C, start stirring at a stirring speed of about 500rpm; after stirring for 5-30 minutes, add the starch solution prepared a...

Embodiment 2

[0036] 1) Preparation of gelatinized starch solution:

[0037] Accurately weigh 4.0 g of edible potato (potato) starch with an electronic balance, measure 100 ml of distilled water with a graduated cylinder, and mix evenly in a 250 ml beaker;

[0038] Place the above-mentioned beaker prepared with the solution in a constant temperature water bath at 50°C, keep the water bath heated for 5 minutes, and continue to slowly stir the solution with a glass stirring rod until the solution becomes a paste, take out the beaker and cool to room temperature, and the paste is obtained complete starch solution;

[0039] Add 1 mol / L NaOH solution dropwise to the gelatinized starch solution, and observe with pH test paper until the pH of the solution is within the range of 9.0;

[0040] 2) Preparation of paraffin oil-starch mixed solution:

[0041] The above-mentioned gelatinized starch solution with adjusted pH value is emulsified with span80 and dispersed with paraffin oil, that is, accur...

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Abstract

A superfine styptic powder is the micron-class porous spherical particles. It is prepared from the potato starch through gelatinizing, regulating pH=8-10, emulsifying by span 80, dispersing in paraffin wax oil, cross-linking with epichlorohydrin, separating by ethyl acetate, washing with absolute alcohol, dewatering, baking, loading in sprayer, and sterilizing by epoxy ethane.

Description

(1) Technical field [0001] The invention relates to a medical hemostatic particle and a preparation method thereof. (2) Background technology [0002] Local hemostatic materials are very important, such as first aid treatment for daily sudden accidents, especially the rescue of war wounds, hospitals often use local hemostatic materials in the wound hemostasis of patients. At present, bandages are mainly used to compress bleeding parts of extremities. Recent studies have found that field dressings with a new hemostatic mechanism different from direct compression can reduce severe bleeding. The ideal pre-hospital dressing should have the characteristics of low cost, good stability, convenient use, and good hemostatic effect. Remove without destroying the new epithelium and blood scab. The more commonly used hemostatic dressings are traditional alginate, collagen and newly emerging collagen complex, fibrin products, chitosan and zeolite. Taehocomd absorbable wound hemostatic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/42C08B37/00
Inventor 孙伟庆沈晶
Owner HANGZHOU SINGCLEAN MEDICAL PROD
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