Method of treating granuloma annulare or sarcoid

A granuloma, annular technology, applied in the field of treatment of granuloma annulare and sarcoid, can solve problems such as long-term implementation

Inactive Publication Date: 2007-07-18
GENENTECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

38 Many of these treatments are associated with potentially harmful side effects and require clinical and laboratory monitoring; many of these treatments cannot be administered long-term due to their cumulative toxicity

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  • Method of treating granuloma annulare or sarcoid

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Embodiment Construction

[0017] DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT

[0018] Granuloma annulare covers a group of uncommon benign granulomatous disorders including focal, disseminated (generalized), subcutaneous, and penetrating types. Disseminated granuloma annulare (DGA), which affects approximately 10% to 15% of patients, occurs primarily in adults and is characterized by multiple discrete or confluent papules with either annular or non-annular appearance. DGA occurs primarily on the trunk and closest extremities, and patients with DGA may present with hundreds of lesions. In about one-third of cases, patients reported itching or burning. Histologically, DGA is generally characterized by areas of collagen alterations and elastotic fibrosis in the middle and upper dermis surrounded by palisades of inflammatory cells; the epidermis appears normal. The inflammatory infiltrate in DGA consists mainly of a mixture of histiocytes (macrophages) and lymphocytes.

[0019] "Alleviation" in the...

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Abstract

The invention provides a method of alleviating a granuloma annulare or a sarcoid disease by administering to a patient having the disease, a therapeutically effective amount of an LFA-1 antagonist.

Description

field of invention [0001] The present invention relates to methods of treatment for granuloma annulare and sarcoid. Background of the invention [0002] Granuloma annulare covers a group of uncommon benign granulomatous disorders including focal, disseminated (generalized), subcutaneous, and penetrating types. Disseminated granuloma annulare (DGA, also known as GGA), which affects approximately 10% to 15% of patients, occurs primarily in adults and is characterized by multiple discrete or confluent papules with either annular or non-circular shape. 1-3 DGA occurs primarily on the trunk and closest extremities, and patients with DGA may present with hundreds of lesions. In about one-third of cases, patients reported itching or burning. 2 Histologically, DGA is generally characterized by areas of collagen alterations and elastotic fibrosis in the middle and upper dermis surrounded by palisading inflammatory cells; the epidermis appears normal. 3-6 The inflammatory infiltra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/28A61K39/395A61P29/00
Inventor 伯纳德·戈菲
Owner GENENTECH INC
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