Micro-prisms array SPR biosensor component

Abstract

The present invention relates to a surface plasmon resonance (SPR) biosensor, especially to a micro prism array SPR biosensor module. The objective of the present invention is to resolve problems in the technology in existence, such as that the operation course to build up a SPR biosensor is two complicated and tedious, and the technological request is too high. Said micro prism array SPR biosensor module comprises a SPR biosensor and prisms which is a micro prism array comprising at least one line prisms, wherein said micro prism array contains a base level which tother side is plated with gold film, silver film and chromium film at positions corresponding to places where the prisms locate. Said micro prism array SPR biosensor module radically simplifies the operation course to build up a SPR sensor; and improves the quality of detection signals at the same time, and is capable of performing a plurality of detections at one time. The sensor module has a low manufacturing cost, and then it is favourable to promote the application of said sensor module in clinical tests.

Description

technical field [0001] The present invention relates to a surface plasmon resonance (SPR) biosensor, in particular to a microprism array SPR biosensor assembly, the sensor assembly includes a microprism array SPR chip and a multi-channel microchip with pins capable of heating or cooling Runner reaction pool. Background technique [0002] Surface plasmon resonance (SPR) technology has developed rapidly in the past ten years because of its high sensitivity and efficient ability to trace the interaction process of biomolecules. The principle of surface plasmon resonance is the collective oscillation effect of electron or charge density propagating along the metal surface. When the incident angle of the incident polarized light satisfies certain conditions, the intensity of the reflected light is the smallest, and the angle at this time is called the resonance angle. When the concentration of substances near the nanometer scale on the surface of the metal film changes, its res...

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Problems solved by technology

And due to the difference in bonding techniques, the thickness of the oil film will be uneven, resulting in disordered film interference fringes, and noise that cannot be eliminated in the detector

[0009] In some detections, it is necessary to adjust and control the reaction temperature in the microchannel of the reaction pool, and it is hoped to control the temperature online. The above-mentioned SPR sensor is difficult to do this. Usually, the temperature-controlled reaction can only be carried out offline, and then take to the instrument for detection

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