Method for preparing artificial dura meter of brain using with bacterial cellulose

Abstract

The invention discloses a method of preparaing artificial dura mater by bacteria cellulose, which steps are crushing moisture film of bacteria cellulose to get bacteria cellulose homogenate; blending the bacteria cellulose homogenate and polyvinyl alcohol solution with 7%-15% concentration in ratio of 1:1-10, water content of the bacteria cellulose homogenate is 95%-98%; then spreading the mixture in a mould with thickness is 0.26 mm-0.90 mm, freezing 20-30 hours in condition of -20--4 DEG C; drying in vacuum freeze dryer to get formed artificial dura mater. The artificial dura mater of the invention have good elasticity and flexibility in hygrometric state, experimental detecting: commonly thickness is 0.18-0.78 mm, water seepage rate is 0, breaking tenacity is 3-7 N / mm2, extensibilityat break is 30-98%, pawn strength is 3-7 N / mm2, which is uncapable of tearing and frilling when sewing. The method of the invention has environmental protective production process, simple production technics, low cost, is suit for spreading.

Description

A kind of method utilizing bacterial cellulose to prepare artificial dura mater technical field The invention relates to a preparation method for implanting or repairing human organ materials, in particular to a method for preparing artificial dura mater by using bacterial cellulose. Background technique Clinically, the human dura mater is often defective due to open injury, tumor erosion, inflammatory destruction, and other craniocerebral diseases. It needs to be repaired in time to prevent cerebrospinal fluid overflow, intracranial infection and other complications. Its repair substitutes include frozen human dura mater, but its source is limited; there are biomembranes obtained through special treatment such as pig peritoneum, fetal membrane, amniotic membrane, or artificial meninges made of pure biological protein, such as collagen artificial dura mater The defect of this kind of product is that it is easy to produce scars and irritations on the brain tissue, and can b...

AI Technical Summary

Problems solved by technology

However, in the existing research on bacterial cellulose, the research on the use of bacterial cellulose to prepare dura mater substitutes and related methods has not been reported after retrieval.