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Degradable soft tissue patch

A soft tissue and patch technology, applied in the field of biodegradable artificial organs, can solve the problems of increasing the chance of infection of implant materials, poor flexibility of polyglactin, restrictions and other problems, and achieve the effect of avoiding long-term complications

Inactive Publication Date: 2007-11-07
徐志飞 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, the clinically available biodegradable mesh is Vicryl mesh (polyglactin 910), which has been used in the repair of chest wall defects and hernias. However, polyglactin has poor flexibility, and its fibers can only adopt a multifilament structure, which increases the chance of infection of implant materials. , and the Vicryl mesh degrades quickly, the complete absorption time is 8-10 weeks, and the mechanical strength maintenance time is only 2-3 weeks. It cannot meet the requirements for large-area tissue defects that require a long support time, so its application is limited.

Method used

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Embodiment 1

[0013] Polydioxanone monofilament fibers with a diameter of 0.28mm were woven on a sample loom by plain weaving method, warp density: 320 threads / 10cm, weft density: 230 threads / 10cm. The warp tightness of the obtained fabric: 89.6%, weft tightness: 64.4%, thickness 0.8mm, mesh gap 200-300μm; then heat-press it at 90°C for 5 seconds; then soak it in 2% collagen After 3 minutes in the solution, take it out, put it in a 40°C oven to dry, repeat the above operation twice; then use 2.0% chitosan coating agent to coat the mesh wall facing the viscera, and dry it in a 40°C oven to set the shape. Repeat the above operation twice to obtain a complete patch material whose inner layer is a mesh support and the surface layer is a coating material, which is sterilized by ethylene oxide, vacuum-dried, sealed and stored at 4°C.

Embodiment 2

[0015] Polydioxanone monofilament fibers with a diameter of 0.20mm are woven into a net on a warp knitting machine with a gauge number of 14-18 needles. The horizontal density is 32 pieces / 5cm. The obtained fabric has a porosity of 72%, a thickness of 0.65 mm, can be cut arbitrarily, and the edges do not fall apart. Then soak it in 2% collagen solution for 3 minutes, take it out, put it in a 40°C oven to dry, repeat the above operation twice; then apply 2.0% chitosan coating agent to the mesh wall facing the viscera, It was dried and shaped in an oven at 40°C, and the above operation was repeated twice. After being sterilized by ethylene oxide, it was vacuum-dried and sealed at 4°C for storage.

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Abstract

The present invention belongs to the field of biomedicine technology, relates to artificial organ, and is especially biodegradable soft tissue patch. The biodegradable soft tissue patch is prepared through weaving porous patch shell in the shape matching the soft tissue to be repaired with poly-p-dioxy cyclohexanone; permeating collagen to cover and seal the pores in the patch shell; covering the side towards the organ with chitosan, sterilizing and drying to complete the patch. The patch of the present invention may be flat one or woven one. The present invention has the active effects, including function of supporting growing tissue in the early stage, and the gradual degradation and absorption to avoid long term complication.

Description

technical field [0001] It belongs to biomedicine, and particularly relates to the technical field of biodegradable artificial organs. Background technique [0002] It is very difficult to repair large tissue defects in the chest wall, abdominal wall, etc., not only need to use suitable repair materials, but also have a suitable repair structure. At present, the widely used artificial patch materials mainly include polypropylene mesh (Marlex, Prolene mesh), polytetrafluoroethylene patch (PTFE, Gore-Tex patch), polyester patch, etc. However, the implantation of traditional artificial materials in the body will increase the chance of wound infection, and postoperative infection is the biggest complication; after long-term implantation, deformation and wrinkles can lead to granulation hyperplasia, pain and discomfort, seroma, infection, and fistula formation Complications such as vascular destruction, so it is necessary to find more ideal organ tissue repair...

Claims

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Application Information

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IPC IPC(8): A61L27/48A61L27/18A61F2/08
Inventor 徐志飞王文祖吴永高秦雄
Owner 徐志飞
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