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Degradable soft tissue patch

A patch and soft tissue technology, applied in the field of biodegradable artificial organs, can solve the problems of increasing the chance of infection of implanted materials, poor flexibility and restrictions of polyglactin, and achieve the effect of avoiding long-term complications

Inactive Publication Date: 2009-08-26
徐志飞 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, the clinically available biodegradable mesh is Vicryl mesh (polyglactin 910), which has been used in the repair of chest wall defects and hernias. However, polyglactin has poor flexibility, and its fibers can only adopt a multifilament structure, which increases the chance of infection of implant materials. , and the Vicryl mesh degrades quickly, the complete absorption time is 8-10 weeks, and the mechanical strength maintenance time is only 2-3 weeks. It cannot meet the requirements for large-area tissue defects that require a long support time, so its application is limited.

Method used

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  • Degradable soft tissue patch
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Examples

Experimental program
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Effect test

Embodiment 1

[0013] Polydioxanone monofilament fibers with a diameter of 0.28mm were woven on a sample loom by plain weaving method, warp density: 320 threads / 10cm, weft density: 230 threads / 10cm. The warp tightness of the obtained fabric: 89.6%, weft tightness: 64.4%, thickness 0.8mm, mesh gap 200-300μm; then heat-press it at 90°C for 5 seconds; then soak it in 2% collagen After 3 minutes in the solution, take it out, put it in a 40°C oven to dry, repeat the above operation twice; then use 2.0% chitosan coating agent to coat the mesh wall facing the viscera, and dry it in a 40°C oven to set the shape. Repeat the above operation twice to obtain a complete patch material whose inner layer is a mesh support and the surface layer is a coating material, which is sterilized by ethylene oxide, vacuum-dried, sealed and stored at 4°C.

Embodiment 2

[0015] Polydioxanone monofilament fibers with a diameter of 0.20mm are woven into a net on a warp knitting machine with a gauge number of 14-18 needles, and the organizational structure is a warp pile (such as figure 2 ) tissue, the vertical density is 55 / 5cm, and the horizontal density is 32 / 5cm. The obtained fabric has a porosity of 72%, a thickness of 0.65 mm, can be cut arbitrarily, and the edges do not fall apart. Then soak it in 2% collagen solution for 3 minutes, take it out, put it in a 40°C oven to dry, repeat the above operation twice; then apply 2.0% chitosan coating agent to the mesh wall facing the viscera, It was dried and shaped in an oven at 40°C, and the above operation was repeated twice. After being sterilized by ethylene oxide, it was vacuum-dried and sealed at 4°C for storage.

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Abstract

The utility model relates to a degradable soft tissue patch, which belongs to biomedicine, and particularly relates to the technical field of biodegradable artificial organs. It is characterized by the use of polydioxanone in the form of flat strips or monofilaments, which is woven into a porous patch shell whose shape matches the soft tissue to be repaired; the pores on the patch are evenly penetrated by collagen, and the holes on the patch are covered; Chitosan, a biological polymer material, evenly covers the shell surface facing the organs, and is sterilized and dried to form a complete patch; there are flat patches and silk-woven patches. The positive effects after implementing the present invention are: in the early stage of implantation, it can play the role of repairing defects and tissue growth scaffolds, replacing traditional non-degradable materials; in the later stage of implantation, it will be gradually degraded and absorbed in the body, and after the tissue repair is completed, it will be completely degraded and absorbed. It is replaced by autologous tissue to avoid long-term complications that may be caused by traditional materials.

Description

technical field [0001] It belongs to biomedicine, and particularly relates to the technical field of biodegradable artificial organs. Background technique [0002] It is very difficult to repair large tissue defects in the chest wall, abdominal wall, etc., not only need to use suitable repair materials, but also have a suitable repair structure. At present, the widely used artificial patch materials mainly include polypropylene mesh (Marlex, Prolene mesh), polytetrafluoroethylene patch (PTFE, Gore-Tex patch), polyester patch, etc. However, the implantation of traditional artificial materials in the body will increase the chance of wound infection, and postoperative infection is the biggest complication; after long-term implantation, deformation and wrinkles can lead to granulation hyperplasia, pain and discomfort, seroma, infection, and fistula formation Complications such as vascular destruction, so it is necessary to find more ideal organ tissue repair materials. [0003...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/48A61L27/18A61F2/08
Inventor 徐志飞王文祖吴永高秦雄
Owner 徐志飞
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