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Magnesium alloy and polymer wire mixed braided composite patch and its application

A magnesium alloy and polymer technology, which is applied in the field of magnesium alloy and polymer wire mixed composite patch, can solve the problems of non-degradable, partially degradable, increased wounds, etc., and achieve the effect of avoiding long-term complications and stabilizing pH

Active Publication Date: 2021-08-03
SHANGHAI JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the above-mentioned patches are mostly made of polymer materials and cannot be degraded or partially degraded
The implantation of these traditional artificial materials in the body will increase the chance of wound infection. Postoperative infection is the biggest complication, and it must be removed by secondary surgery after infection.

Method used

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  • Magnesium alloy and polymer wire mixed braided composite patch and its application
  • Magnesium alloy and polymer wire mixed braided composite patch and its application

Examples

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Effect test

preparation example Construction

[0027] The preparation method of the magnesium alloy wire in the present invention is: turning the cylindrical blank for wire extrusion of a certain height; performing hot extrusion on the cylindrical blank for wire extrusion at a certain temperature to obtain a wire blank with a diameter of φ1-2mm ;Thin wires with different wire diameters can be obtained by multi-pass drawing, rolling deformation and auxiliary heat treatment on the wire blank. The preparation method of the polymer filament is as follows: the absorbable polymer (polylactic acid, polycaprolactone, collagen) is melted and extruded to prepare the polymer filament.

[0028] The morphology of the biodegradable mixed weaving composite patch prepared in the present invention can be as follows figure 1 As shown, it can also be figure 2 shown.

Embodiment 1

[0030] 1) The Mg-Zn-Zr alloy thin wire with a circular cross-section and a diameter of 0.05 mm prepared by the above method and the polylactic acid polymer wire with a diameter of 0.05 mm are braided into a thin rope on a braiding machine, and then used The rope is woven into a net, and the size of the net can be cut arbitrarily.

[0031] 2) After electrolytic polishing, cleaning, drying, packaging and sterilization, it is ready for use.

[0032] The thickness of the final product is 0.1mm, and the area of ​​a single mesh is 0.1mm 2 .

Embodiment 2

[0034] 1) Mg-Zn-Gd-based alloy filaments with an elliptical cross-section, a major axis of 0.05 mm and a minor axis of 0.04 mm and a circular cross-section with a diameter of 0.1 mm were prepared by the above method. The polycaprolactone polymer thread is woven into a net on the knitting machine, which can be cut arbitrarily.

[0035] 2) After electropolishing and cleaning.

[0036] 3) Degradable coating treatment.

[0037] 4) Dry, package, and sterilize before use.

[0038] The thickness of the final product is 0.2mm, and the area of ​​a single mesh is 1mm 2 .

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Abstract

The invention provides a magnesium alloy and polymer wire mixed-weaving composite patch and its application. The patch is made of magnesium alloy wire and degradable polymer wire and has a network structure. The advantages of the present invention are: 1. The patch can be completely degraded, and is gradually absorbed and metabolized by the human body during the recovery process of the disease. The patch has a good supporting effect at the initial stage of implantation, and it is expected to completely degrade and absorb into autologous tissue after tissue repair is completed. 2. By adjusting the size, appearance and weaving method of the wire, different types of composite patches can be obtained, which have different strengths and degradation and absorption times, and can be suitable for different medical conditions.

Description

technical field [0001] The invention relates to a composite patch made of magnesium alloy and polymer wire and its application, which belongs to the technical field of medical consumables. Background technique [0002] Mesh has a wide range of clinical applications in disease treatment and plastic surgery. On the one hand, many disease treatments require the use of tissue repair patches. For example, it is very difficult to repair large tissue defects in the chest wall, abdominal wall, etc., and patches are often used in clinical surgical treatment. Secondly, a hernia means that an organ leaves its original location and enters another location through a weak point or defect or a hole in the human body. Mesh is also needed in the process of surgical treatment. Thirdly, female pelvic floor dysfunction is a gynecological disease with stress urinary incontinence, pelvic organ prolapse and chronic pelvic pain as the main symptoms. Compared with hysterectomy, it improves the sa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/34A61L27/32A61L27/18A61L27/04A61L27/50A61L27/58A61L31/10A61L31/08A61L31/06A61L31/02A61L31/14
CPCA61L27/047A61L27/18A61L27/32A61L27/34A61L27/50A61L27/58A61L31/022A61L31/06A61L31/086A61L31/10A61L31/14A61L31/148A61L2430/00C08L67/04
Inventor 黄华袁广银
Owner SHANGHAI JIAOTONG UNIV
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