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Oral solution

A technology for oral solutions and solvents, which is applied in the direction of urinary system diseases, organic active ingredients, and medical preparations containing active ingredients, etc. It can solve problems such as difficulty in swallowing, slow drug dissolution, and troubles for patients, and achieve high bioavailability. The effect of stable properties and accurate dosage

Inactive Publication Date: 2008-01-23
李献阳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The dosage forms currently on the market are tablets and capsules, which have the advantages of relatively simple manufacturing process and good drug stability, but they often cause troubles for the elderly and patients with dysphagia. Such reasons make the disintegration and drug dissolution slow, thereby affecting the full absorption of the drug. Making silodosin into an oral solution has the advantages of good drug absorption, little influence by food, fast absorption, high bioavailability, etc., and can avoid the difficulties of tablets and capsules at the same time. Disadvantages of swallowing, especially for the elderly

Method used

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  • Oral solution
  • Oral solution

Examples

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Effect test

Embodiment 1

[0027] Prescription: silodosin 20g

[0028] Ethanol (99.5%) 200ml

[0029] Sorbitol 500g

[0030] Stevioside 50g

[0031] water 2000ml

[0032]

[0033] 1000 pieces

[0034] Process: Dissolve the main drug silodosin in ethanol and stir to dissolve it completely. Then add the full amount of distilled water or deionized water, and add sorbitol and stevioside, stir to dissolve them, and further pack, seal, check and pack.

Embodiment 2

[0036] Prescription: silodosin 20g

[0037] Hydroxypropyl beta-cyclodextrin 100g

[0038] Glucose 200g

[0039] Apple essence 2g

[0040] water 2000ml

[0041]

[0042] 1000 pieces

[0043] Process: Dissolve silodosin and hydroxypropyl β-cyclodextrin in 1600ml distilled water or deionized water, stir to dissolve them completely, add glucose and apple essence to the solution, add water to the full amount, further sterilize, subpackage, seal, Inspection, packing.

Embodiment 3

[0045] Prescription: silodosin 20g

[0046] Cyclodextrin 50g

[0047] D-Mannitol 200g

[0048]Lemon essence 5g

[0049] water 60g

[0050]

[0051] 1000 pieces

[0052] Process: Dissolve silodosin and cyclodextrin in 1600ml of distilled or deionized water, stir to dissolve completely, add D-mannitol, lemon essence, and apple essence to the solution, add water to the full amount, further sterilize, subpackage, and seal , inspection, packaging.

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Abstract

The invention provides an oral solution for curing dysuria, which takes silodosin as main active ingredient or silodosin prodrug or pharmaceutically acceptable salt. The oral solution, which is made of water, ethanol or the mixture of the two, overcomes the defects of difficult taking, slow dissolving out and low biological utilization rate in tablet, capsule and other solid preparations. With stable fluid quality, the oral solution has excellent compliance and biologic utilization rate and can be best taken by elder patients.

Description

technical field [0001] The invention relates to an oral solution, in particular to an oral solution for treating dysuria. Background technique [0002] Silodosin is an alpha 1 - Adrenoceptor antagonists, effective in voiding disorders associated with benign prostatic hyperplasia. Benign prostatic hyperplasia (BPH) is one of the common diseases in elderly men, characterized by non-malignant enlargement of the prostate. More than 50% of the elderly aged 60 or over suffer from this disease, and more than 90% of the elderly aged 85 and over have the disease. An enlarged prostate can press on the urethra, causing poor urine flow through the bladder and even blocking the bladder outlet. Activation of alpha-adrenoceptors present in the human prostate aggravates symptoms of urethral obstruction and dysuria. Therefore, by blocking the binding of α-adrenergic receptors, the obstructed prostate smooth muscle can be relaxed, thereby improving symptoms. In pair silodosin with alpha ...

Claims

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Application Information

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IPC IPC(8): A61K31/4045A61P13/08
Inventor 李献阳
Owner 李献阳
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