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Application of clostridium butyricum, condensate bacillus and bifidobacteria in the preparation of medicament for preventing and treating mouth ulcer

A technology of bacillus coagulans and bifidobacterium, applied in the field of biopharmaceuticals

Inactive Publication Date: 2008-03-05
QINGDAO EASTSEA PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Also do not have a kind of comparatively ideal drug treatment oral ulcer at present, especially the medicine that prevents oral ulcer recurrence does not have clinically at all.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0017] Example 1, Clostridium butyricum viable bacteria powder preparation:

[0018] Take a live strain tube of Clostridium butyricum, dissolve it in a sterilized 100ml Erlenmeyer flask filled with 10ml normal saline and glass beads, activate for 10 minutes, use a 1ml sterile pipette to draw 1ml of the bacterial suspension to inoculate a 50ml amplified flask Culture medium in a 250ml Erlenmeyer flask, placed in a rocking bed at 37°C constant temperature oscillation (190rpm) for 24 hours, transferred to a 2500ml baffle Erlenmeyer flask equipped with 450ml expansion medium, 37°C constant temperature oscillation culture for 24 hours, no microscopic examination Then transfer the miscellaneous bacteria into the seed tank with 4.5L expansion medium, anaerobic culture (aeration volume 3:1) for 24 hours, and transfer to the fermenter with 45L fermentation medium after microscopic examination without miscellaneous bacteria , 37 ℃ anaerobic culture for 24 hours, microscopic examination ...

example 2

[0019] Example 2, Clostridium butyricum live bacteria capsule preparation

[0020] Composition % (weight)

[0021] Clostridium butyricum live bacteria powder 20.00 parts

[0022] Microcrystalline cellulose 40.00 parts

[0023] Glucose 40.00 parts

[0024] Fully mix the above-mentioned components in groups 1 to 3, and then use conventional filling capsule technology to make capsules according to unit doses.

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PUM

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Abstract

The present invention discloses new medicinal use of Clostridium butyricum, Bacillus coagulans and bifidobucterium. Clostridium butyricum, Bacillus coagulans and bifidobucterium are applied alone or together as the active medicine component for live microbe preparation for treating stomatocace and preventing the recurrence of stomatocace.

Description

technical field [0001] The present invention relates to the new application of Clostridium butyricum, Bacillus coagulans and Bifidobacterium, in particular to the use of Clostridium butyricum, Bacillus coagulans and Bifidobacterium as active ingredients in the preparation of medicines for treating oral ulcers and preventing recurrence of oral ulcers The application belongs to the field of biopharmaceuticals. Background technique [0002] Oral ulcer is the most common oral mucosal disease, with a general incidence rate of 5% to 25%. It recurs and lasts for decades, causing great pain to the patient and seriously affecting the quality of life of the patient. Traditional medicine believes that its etiology is complex and its pathogenesis is unclear, which may be related to factors such as viruses, bacteria, immunological abnormalities, mental nerves, microcirculation disorders, and genetics. Also do not have a kind of comparatively ideal drug treatment oral ulcer at present, e...

Claims

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Application Information

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IPC IPC(8): A61K35/74A61K9/08A61K9/10A61K9/14A61K9/20A61K9/48A61P1/02A61K35/742A61K35/745
CPCA61K35/745A61K35/742A61K35/74A61P1/02A61P1/04A61K2300/00
Inventor 崔云龙
Owner QINGDAO EASTSEA PHARMA
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