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Azithromycin derivative and application thereof

A technology of azithromycin and derivatives, applied in the field of azithromycin derivatives

Inactive Publication Date: 2010-12-22
SHANGHAI INST OF PHARMA IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Formula I

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  • Azithromycin derivative and application thereof
  • Azithromycin derivative and application thereof
  • Azithromycin derivative and application thereof

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Abstract

The present invention discloses one kind of azithromycin derivative as shown and its pharmaceutically acceptable salt. The present invention also discloses the application of the azithromycin derivative in preparing medicine for preventing and treating bacterial infection diseases.

Description

technical field The invention discloses an azithromycin derivative and application thereof. Background technique Erythromycin is still widely used because of its good antibacterial activity and safety. In the 1980s, the second-generation macrolide antibiotics such as clarithromycin, roxithromycin, dirithromycin, and azithromycin came out successively. Compared with erythromycin, this type of antibiotic has enhanced acid resistance, expanded antibacterial spectrum, and improved pharmacokinetic properties. It has strong antibacterial activity against Gram-positive bacteria, some Gram-negative bacteria, mycoplasma, etc., and has been widely used by these antibiotics. A medicine for treating infections caused by bacteria. Some of them have been used clinically as excellent antibiotics. For example, azithromycin (see U.S. Patents USP 4,474,768 and USP 4,517,359 J.Chem.Research (S) (1988) 152, J.Chem.Research (M) (1988) 1239 ) has the following structure: However, these ant...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/08A61K31/7052A61P31/04
Inventor 沈舜义王宝霞葛涵
Owner SHANGHAI INST OF PHARMA IND CO LTD