Application of montmorillonite and composition containing montmorillonite in preparing medicine for treating hyperuricemia and gout

A technology of hyperuricemia and montmorillonite, applied in the field of medicine, can solve problems such as easy deposition of urate in the urinary tract, renal colic, and renal dysfunction

Inactive Publication Date: 2008-04-30
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The biggest disadvantage of uric acid excretion drugs is that the excreted urate is easy to deposit in the urinary tract, causing renal colic and renal function damage

Method used

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  • Application of montmorillonite and composition containing montmorillonite in preparing medicine for treating hyperuricemia and gout
  • Application of montmorillonite and composition containing montmorillonite in preparing medicine for treating hyperuricemia and gout

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0056]Preparation of uric acid suspension: put 1 g of uric acid in 1 L of boiling water, adjust the pH to 7.4, then heat to 95° C., cool at room temperature, stir, and filter to obtain microcrystalline sodium urate. Make a 100mg / L suspension with sterile normal saline before use, and set aside.

[0057] Modeling method: 60 SD rats were selected and randomly divided into 6 groups according to body weight: ① blank group, ② model group, ③ prednisone (50 mg / kg) group and ④ ~ ⑥ montmorillonite 2, 1, 0.5 g / kg group, 10 rats in each group. Each group was intragastrically administered with a volume of 10ml / kg, and the blank group and model group were given normal saline. One hour after the administration, the volume of the right hind paw of each rat was measured twice, and the average value was taken as the volume of the paw of the rat before inflammation. Except for the blank group, 0.1 mL of uric acid suspension was subcutaneously injected into the right hind paw of each mouse 1 h...

Embodiment 1

[0063] Embodiment 1: Natural montmorillonite is made into powder or capsule after being calcined or roasted, crushed and sieved. Every sachet of powder contains 3g of montmorillonite, and each capsule contains 0.5g of montmorillonite.

Embodiment 2

[0064] Example 2: Natural montmorillonite is calcined or roasted, crushed and sieved to make a powder with an average particle size of 2 to 3 microns: its expansion capacity is 27.0 (ml / g); it is mixed with auxiliary materials. Made into powder or capsule, packed for later use.

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Abstract

Montmorillonite and the compositions containing montmorillonite are applied in preparing and treating hyperuricemia and gout. The reason of the hyperuricemia and the gout is that uric acid is over applied and / or hypouresis, thereby resulting in a metabolic disease with the concentration of hematuresis acid increasing. About one third uric acid of a normal man is discharged from intestinal canal and the uric acid in the intestinal canal can be reabsorbed. During the hyperuricemia and gout, the ratio of the uric acid discharged from the intestinal canal increases. The uric acid, fore-body xanthine and hypoxanthine with positive charge can be adsorbed by the montmorillonite. Oral montmorillonite can absorb the uric acid which is diffused into the intestinal canal from blood, thereby the uric acid is discharged out of the body, and the resorption of the uric acid is stopped, thereby lowering the concentration of hematuresis acid and reaching the aim of preventing and curing the hyperuricemia and gout. Furthermore, the montmorillonite has the advantages of non-digestion and absorption, non-penetration into blood circulation and no side effect.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a montmorillonite and a composition containing the montmorillonite as preparation for treating hyperuricemia and gout. Background technique [0002] The incidence of hyperuricemia and gout: With the continuous improvement of people's living standards, changes in diet structure and living habits, the extension of average life expectancy, and the improvement of awareness and diagnosis, the incidence of hyperuricemia and gout is increasing year by year , the age of onset is younger. In 1980, Fang Qi et al. reported that the incidence of hyperuricemia in my country was 1.4%. In 1998, Du Hui et al. investigated in Shanghai and showed that the incidence of hyperuricemia rose to 10.1%, and the incidence of gout reached 0.34%. From the 1980s to the 1990s, the incidence of gout was between 0.27% and 1.0%. In 2003, a survey by Shao Jihong and others showed that the incidence of hyperuri...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K33/06A61P19/06
Inventor曹永孝孟新芳刘静张寅莉龙丽辉李军涛马朝高洁马婕群周良震
OwnerXI AN JIAOTONG UNIV