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Extract for treating hyperuricemia as well as preparation method and application thereof

A technology for hyperuricemia and extract, applied in the field of plant extract and preparation, can solve problems such as large side effects, achieve the effects of improving blood creatinine level, reducing kidney damage and effective blood uric acid concentration

Pending Publication Date: 2022-05-20
SHANDONG UNIV OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The purpose of the present invention is to provide an extract for treating hyperuricemia and its preparation method and application, which are used to solve the problem of large side effects of existing drugs for treating hyperuricemia

Method used

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  • Extract for treating hyperuricemia as well as preparation method and application thereof
  • Extract for treating hyperuricemia as well as preparation method and application thereof
  • Extract for treating hyperuricemia as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The preparation of embodiment 1 pomegranate peel extract

[0040] ①Powder the dried pomegranate peel with a pulverizer, pass through a 60-mesh sieve, weigh 100g, wrap it with filter paper and make it into a medicine bag;

[0041] ② Add an appropriate amount of petroleum ether to the Soxhlet extractor (without the Chinese medicine bag in the extraction tube, and leave about 1 / 3 of the liquid in the extraction bottle), and extract at 40°C until the liquid in the extraction tube with the drug bag appears It is colorless and transparent, and the excess oil in the pomegranate peel is removed.

[0042] ③ Dry the degreased medicine bag, put it into a beaker, pour 700mL of 75% ethanol aqueous solution into it, seal the mouth of the cup, and let it stand overnight.

[0043] ④Assemble the Soxhlet extraction device in order, pour the medicine pack and 75% ethanol aqueous solution into the extractor at the same time; turn on the heater, extract at 70°C for 8 hours, until the 75% e...

Embodiment 2

[0047] The preparation of embodiment 2 pomegranate peel extract oral agent-1

[0048] Accurately weigh 50 mg of the pomegranate peel extract powder prepared in Example 1, add 10 mL of 0.5% carboxymethylcellulose sodium (CMC-Na) aqueous solution, mix with a vortex oscillator, and ultrasonicate for 3 minutes to make a uniform suspension ; The final concentration of pomegranate peel extract is 50mg / mL.

Embodiment 3

[0049] The preparation of embodiment 3 pomegranate peel extract oral agent-2

[0050] Accurately weigh 200 mg of the pomegranate peel extract powder prepared in Example 1, add 10 mL of 0.5% carboxymethylcellulose sodium (CMC-Na) aqueous solution, mix with a vortex oscillator, and ultrasonicate for 3 minutes to make a uniform suspension ; The final concentration of pomegranate peel extract is 200mg / mL.

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Abstract

The invention relates to the technical field of traditional Chinese medicine pharmacy, in particular to an extract for treating hyperuricemia and a preparation method and application thereof. The preparation method comprises the following steps: (1) mixing dried and crushed pomegranate rind with an aqueous solution of an organic solvent with the volume concentration of 0-90%, extracting, and filtering to obtain an extracting solution I; (2) removing water and an organic solvent in the extract I through a rotary evaporator at 50-70 DEG C to obtain an oily mixture; (3) mixing the oily mixture with an organic solvent; and (4) centrifuging, removing the organic solvent, and drying to obtain the plant extract. The extract disclosed by the invention has a good effect of reducing the uric acid activity of hyperuricemia, and the content of blood uric acid can be quickly and effectively reduced; the kidney function index can be effectively improved; the defect that the existing medicine for treating hyperuricemia is large in side effect is effectively overcome.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine pharmacy, in particular to a plant extract, a preparation method and an application. Background technique [0002] Hyperuricemia (HUA) is caused by excessive production and / or low excretion of uric acid in the human body, and is related to abnormal metabolism of purine nucleotides in the body. When uric acid accumulates to a certain extent in the body of patients with hyperuricemia, it will cause a series of metabolic diseases in the body. Such as gouty arthritis, the uric acid content in the blood increases, and the urate concentration reaches saturation, forming crystals, which accumulate in soft tissues, causing lesions and inflammatory reactions, resulting in joint deformation and tophi. The second is uric acid nephropathy, in which saturated blood urate forms crystals and deposits in the kidneys, causing kidney damage, and severe cases can lead to renal insufficiency. A...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P19/06
CPCA61K36/185A61K9/0053A61P19/06A61K2236/333A61K2236/53A61K2236/51A61K9/145
Inventor 宋新华孙文龙黄裕鸿刘超孙金月李义平
Owner SHANDONG UNIV OF TECH
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