Jianweixiaoshi orally disintegrating tablets and preparation method

A technology of orally disintegrating tablets and disintegrants, which is applied in the field of orally disintegrating tablets and its preparation, can solve problems such as difficulty in taking medicine, and achieve the effects of large-scale production, convenient taking, and low production cost

Active Publication Date: 2008-05-28
JIANGZHONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the patent application number 200510072047.X discloses a Xinliwan orally disintegrating tablet and its preparation method; the patent application number 200410037044.8 discloses a Liuwei Dihuang orally disintegrating tablet and its preparation method, etc.; There are a large number of orally disintegrating tablet patents made from traditional Chinese medicine extracts and effective parts, but there are no reports on orally disintegrating tablet preparations made from five flavors of traditional Chinese medicines including heterophylla heterophylla, tangerine peel, yam, fried malt, and hawthorn
Develop Jianwei Xiaoshi orally disintegrating tablets to solve the problem of difficulty in taking medicine for elderly patients and other patients with difficulty in swallowing existing preparations, improve patients' compliance with taking medicine, and make it more convenient for patients to take medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Prescription: 1000 tablets 0.6g / tablet

[0026] Chinese herbal extract 75.0g

[0027] Mannitol 373.9g

[0028] Microcrystalline Cellulose 75.0g

[0029] Crospovidone 60.0g

[0030] Citric acid 3.8g

[0031] Aspartame 0.3g

[0032] Hawthorn essence 1.5g

[0033] Micronized silica gel 6.0g

[0034] Magnesium Stearate 3.0g

[0035] Gelatin 1.5g

[0036] 2. Preparation method

[0037] Step 1: Preparation of traditional Chinese medicine extract: Weigh 228.6g of Radix Pseudostellariae, 22.9g of Tangerine Peel, 171.4g of Chinese Yam, 171.4g of Malt (stir-fried), 114.3g of Hawthorn according to the prescription ratio, add water and decoct twice, each time for two hours, Combine the decoctions, filter, concentrate the filtrate to a certain amount, carry out alcohol precipitation to make the alcohol content 70%, let it stand still, take the supernatant and concentrate it to 70°C when the relative density is 1.05, spray dry, and set aside.

[0038] The second step: ta...

Embodiment 2

[0043] 1. Prescription 1000 tablets 0.6g / tablet

[0044] Chinese herbal extract 50.0g

[0045] Sorbitol 322.5g

[0046] Erythritol 50.0g

[0047] Microcrystalline Cellulose 75.0g

[0048] Crospovidone 60.0g

[0049] Sodium carboxymethyl starch 20.0g

[0050] Citric acid 4.0g

[0051] Aspartame 0.5g

[0052] Hawthorn essence 3.0g

[0053] Micronized silica gel 4.0g

[0054] Glyceryl Behenate 6.0g

[0055] Hydroxypropyl methylcellulose 5.0g

[0056] 2. Preparation method

[0057] Step 1: Preparation of Chinese medicine extract: Weigh 228.6g of Radix Pseudostellariae, 22.9g of Tangerine Peel, 171.4g of Chinese Yam, 171.4g of Malt (stir-fried), and 114.3g of Hawthorn according to the prescription ratio, add water and decoct twice, each time for two hours, Combine the decoctions, filter, concentrate the filtrate to a certain amount, carry out alcohol precipitation to make the alcohol content 60%, let it stand still, take the supernatant and concentrate it to 70°C when th...

Embodiment 3

[0063] 1. Prescription

[0064] 1000 pieces 0.5 g / piece

[0065] Chinese herbal extract 100.0g

[0066] Erythritol 100.0g

[0067] Lactose 130.0g

[0068] Microcrystalline Cellulose 75.0g

[0069] Crospovidone 50.0g

[0070] Low-substituted hydroxypropyl cellulose 25.0g

[0071] Citric acid 3.0g

[0072] Cyclamate 3.0g

[0073] Hawthorn essence 2.0g

[0074] Micronized silica gel 5.0g

[0075] Glyceryl Behenate 5.0g

[0076] Eudragit  E 100 2.0g

[0077] 2. Preparation method

[0078] Step 1: Preparation of traditional Chinese medicine extract: weigh 228.6g of Radix Pseudostellariae, 22.9g of Tangerine Peel, 171.4g of Chinese Yam, 171.4g of Malt (stir-fried), and 114.3g of Hawthorn according to the prescription ratio, add water and decoct twice, each time for two hours, The decoctions were combined and filtered, and the filtrate was ultrafiltered with an ultrafiltration membrane with a molecular weight cut-off of 5000. When the ultrafiltrate...

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PUM

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Abstract

The invention relates to an orally disintegrating tablet which is prepared by the Chinese medicinal materials of tangerine peel, common yam rhizome, heterophylly falsestarwort root, stir-fried malt and hawthorn fruit; the invention takes the Chinese medicinal materials as raw materials and uses certain proportion of pharmaceutically excipients for the preparation; the invention is prepared by the raw materials with the following weight percentages: 5 to 20 percent traditional Chinese medicine extract, 40 to 80 percent filler, 5 to 30 disintegrating agent, 0.5 to 5 percent flavoring agent, 0.5 to 3 percent glidant and 0.3 to 2 percent lubricant; the disintegrating tablet can be disintegrated in the oral cavity rapidly, the taste is good, so the invention is especially applicable to the elderly people, children and the patients with the difficulty in swallowing for administration.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound orally disintegrating tablet dosage form, in particular to an orally disintegrating tablet that does not need to be chewed, can disintegrate rapidly in the oral cavity, and has a good taste, and is especially suitable for some elderly people, children and patients with difficulty in swallowing. Preparation. Background technique [0002] Orally disintegrating tablets are a new dosage form emerging in recent years. Compared with ordinary tablets, this dosage form only needs to put the tablet in the mouth, without water or a small amount of water, and without chewing. After a while, the drug will reach the absorption tissues and organs with saliva , this dosage form is especially suitable for some elderly people, children and patients who have trouble swallowing or those who go out and suffer from dehydration. It has the characteristics of convenient taking, quick effect and high bioavailab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K9/20A61P1/14
Inventor 季巧遇王再全卢建中
Owner JIANGZHONG PHARMA
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