The invention discloses a large-scale ball mill lining board and a preparation method thereof, and belongs to the technical field of wear-resistant materials. The method comprises the following steps: firstly, mixing, heating and fusing steel scraps, a carburetant, ferrochrome, nitrided ferrochrome, ferroniobium, ferroboron, ferromanganese and ferrosilicon in an electric furnace; when the temperature of molten steel reaches 1580-1600 DEG C, adding aluminum, and deoxidizing; adjusting the chemical components of the molten steel in the furnace and the mass fractions of the chemical components to be 0.70%-0.85% of C, 1.8%-2.0% of Cr, 0.05%-0.09% of N, 0.12%-0.18% of Nb, 0.6%-1.0% of Mn, 0.25%-0.60% of Si, 0.004%-0.008% of B, 0.05%-0.08% of Al, less than 0.04% of S, less than 0.05% of P and the balance of Fe and inevitable race impurity elements; and carrying out microalloying treatment on the molten steel, casting a lining board, and carrying out thermal treatment on the lining board. The large-scale ball mill lining board has the characteristics of high hardness, good abrasive resistance and the like, and has a good effect on popularization and application.