The invention discloses a 3D-printing cervical vertebra side block screw guide embedded plate and a manufacturing method thereof. The embedded plate is printed through 3D printing technology and comprises one or multiple guide plates, one to multiple side block screw guide screw paths and one to multiple spinous holes formed in the center or one side of the guide plate, the upper portion of the guide plate is a plane, the curved surface of the bottom of the guide plate is reversely uniform with a cervical vertebra side block vertebral plate, the curved surface of the bottom of the guide plate is uniform to the outer side of a side block, and the plane of the upper portion of the guide plate extends to an outlet, in the upper-portion plane, of the corresponding screw path and then extends for 2-5mm. When multiple guide plates are arranged, connecting components are arranged among the guide plates. In order to guarantee stability of the guide embedded plate, fixing needles different in amount are arranged on the guide plates, and fixing clamps are arranged beside the spinous holes. The 3D-printing cervical vertebra side block screw guide embedded plate is simple and reasonable in structure and convenient to use, a screw feeding guide screw path can be provided for cervical vertebra side block screws effectively, accuracy (depth and direction) of screw feeding is guaranteed, and operating difficulty and operating risk are reduced.