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Monodisperse boric acid cross-linked polyvinyl alcohol embolism microsphere and preparation method thereof

A polyvinyl alcohol embolization microsphere, polyvinyl alcohol embolization technology, applied in the field of biomedicine, can solve the problems of poor monodispersity, poor sphericity, uneven size and the like, and achieves good monodispersity and uniform appearance , the effect of simple production process

Active Publication Date: 2021-12-31
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the problems of poor sphericity, non-uniform size, poor monodispersity and toxic cross-linking agent used in the preparation of existing PVA embolization microspheres, the present invention provides monodisperse boric acid cross-linked PVA embolization microspheres and Its preparation method is to improve the monodispersity of embolization microspheres while realizing rapid continuous non-toxic preparation of embolization microspheres, and reduce the possibility of misembolization

Method used

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  • Monodisperse boric acid cross-linked polyvinyl alcohol embolism microsphere and preparation method thereof
  • Monodisperse boric acid cross-linked polyvinyl alcohol embolism microsphere and preparation method thereof
  • Monodisperse boric acid cross-linked polyvinyl alcohol embolism microsphere and preparation method thereof

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Experimental program
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Embodiment 1

[0044] In this embodiment, monodisperse crosslinked PVA embolization acid microspheres, the following steps:

[0045] (1) In preparation phase, the external phase fluid and a liquid collecting

[0046] Phase fluid formulation: polyvinyl alcohol and boric acid to deionized water, stirring until completely dissolved in an oil bath at 98 deg.] C, and then cooled to room temperature, placed in a vacuum oven evacuated at room temperature to the solution to remove the air bubbles, to give the phase fluid; fluid phase in deionized water, polyvinyl alcohol, boric acid mass ratio of 1: 0.05: 0.0005.

[0047] The outer fluid formulation: The oil-soluble surfactant is dissolved in n-octanol Span80 give outer fluid; outer phase phase fluid, and n-octanol Span80 mass ratio of 1: 0.04.

[0048] Collecting liquid formulation: The granular sodium hydroxide was dissolved in n-octanol, they are collected liquid; collecting liquid, the mass ratio of n-octanol and sodium hydroxide was 1: 0.03.

[004...

Embodiment 2

[0058] In this embodiment, monodisperse crosslinked PVA embolization acid microspheres, the following steps:

[0059] (1) In preparation phase, the external phase fluid and a liquid collecting

[0060] The inner fluid phase in Example 1, the same as the external phase fluid and the fluid collection.

[0061] (2) Preparation of monodisperse borate crosslinked PVA embolic microspheres

[0062] The adopted structure figure 2 A capillary microfluidic device illustrated, the inner diameter thereof at the outlet of the injection tube is 60 m, the inner diameter of the collection tube is 300μm. The injection tube with fluid injection pump input microfluidic device 1, 2, monodispersed outer fluid input microfluidic device with a syringe pump collection tube in the collector tube 2 W / O emulsion using filled with collecting container for collecting the liquid monodispersed W / O emulsion, sodium hydroxide in a basic environment provided in the collection liquid, PVA and boric acid initiat...

Embodiment 3

[0085] In this embodiment, a single-dispersed boric acid cross-linking PVA embolization microsphere is prepared, and the steps are as follows:

[0086] (1) Formulate inner phase, outer phase fluid and collect liquid

[0087] As in the inner phase fluid, outer phase fluid, and collecting liquid in Example 1.

[0088] (2) Preparation of single-dispersed boric acid cross-linking PVA embolization microspheres

[0089] Use structure figure 2 The first-stage capillary microfluidic device, the inner diameter of the injection tube is 60 μm, and the inner diameter of the collection tube is 300 μm. In the injection tube 1 of the inner phase fluid input microfluidic device, the outer phase fluid is input to the collecting tube 2 of the microfluidic device in the injection of the microfluidic device, and a single-dispersed W / O emulsion is formed in the collection tube 2. The container of the collecting liquid collects the single-dispersed W / O emulsion, in an alkaline environment supplied ...

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Abstract

The invention provides a monodisperse boric acid cross-linked polyvinyl alcohol embolism microsphere, the base material of the microsphere is boric acid cross-linked polyvinyl alcohol, the embolism microsphere is spherical, the particle size variation coefficient does not exceed 5%, and the particle size is 30-500 [mu]m. The invention also provides a preparation method of the embolism microsphere, which comprises the following steps: inputting an internal phase fluid into an injection tube of a microfluid device, inputting an external phase fluid into a collecting tube of the microfluid device, forming a monodisperse water-in-oil emulsion in the collecting tube, and collecting the monodisperse water-in-oil emulsion by adopting a container filled with collecting liquid, and in an alkaline environment provided by sodium hydroxide in the collected liquid, initiating a polymerization reaction of polyvinyl alcohol and boric acid in a liquid drop water phase of the monodisperse water-in-oil emulsion, and after sufficient polymerization reaction, converting the monodisperse water-in-oil emulsion into the monodisperse boric acid crosslinked polyvinyl alcohol embolism microspheres. According to the method, the monodispersity of the embolism microspheres is improved while rapid, continuous and non-toxic preparation of the embolism microspheres is realized, and the possibility of mistaken embolism is reduced.

Description

Technical field [0001] The present invention belongs to the field of biomedical technology, and involves embolization microspheres and its preparation processes, more particularly, involving single-dispersed boric acid crosslinking polyvinyl alcohol, microspheres and preparation methods thereof. Background technique [0002] The solid tumor is developed to the middle and late, and the surgery is often non-excreted. The treatment of embolism has become an alternative to the agency, embolization treatment refers to the blood vessels near the tumor near the tumor through minimally invasive surgery to block the blood supply of tumors. . Compared to ordinary chemotherapy or radiotherapy, embolization treatment can reduce side effects, improve patient compliance, and improve the treatment efficiency. [0003] There are many solid embolic materials that can be used for embolization treatment. Since polyvinyl alcohol (PVA) has good biocompatibility and hydrophilicity, materials are non-t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/06A61L24/00
CPCA61L24/06A61L24/001A61L24/00A61L2400/06C08L29/04
Inventor 褚良银杨仕豪巨晓洁汪伟邓传富谢锐刘壮张婷婷
Owner SICHUAN UNIV
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