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Method for preparing hydroxyl carthamus tinctorius yellow color A

A technology of hydroxysafflower and yellow pigment, which is applied in the field of preparation of hydroxysafflower yellow A, can solve the problems of being unsuitable for industrial production, and achieve the effects of easy elution and regeneration, low production cost and low price

Active Publication Date: 2008-07-09
山西华卫药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When the gel chromatographic column is separated, another safflower chalcone component is mixed with HSYA, and it needs to be refined with preparative polyamide thin-layer plates to prepare HSYA, which is not suitable for industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Take 0.4Kg of dried safflower, extract twice with 12Kg of deionized water, the extraction temperature is 60°C, the extraction time is 45min, the extracts are combined, filtered, and the filtrate is concentrated under reduced pressure at 60°C to a water extract with a specific gravity of about 1.10; the water extract Separation on a polyamide column (diameter-to-height ratio: 1:20), with a loading volume of 1:3. First rinse 3 column volumes with deionized water, then rinse 4 column volumes with 50% ethanol, collect the eluate, concentrate under reduced pressure at 60°C to a specific gravity of 1.05 to obtain a preliminary separation concentrate; the preliminary separation concentrate is put on the column For MDS-5 (diameter-to-height ratio: 1:10), the loading volume is 0.5:1. First, wash 2 column volumes with 10% ethanol, then wash 4 column volumes with 20% ethanol, and collect 20% ethanol. lotion. Thin-layer chromatography detection (developing solvent is ethyl acetate...

Embodiment 2

[0022] Take 0.4Kg of dried safflower, extract twice with 15Kg of deionized water, the extraction temperature is 80°C, the extraction time is 60min, the extracts are combined, filtered, and the filtrate is concentrated under reduced pressure at 60°C to a water extract with a specific gravity of about 1.05; the water extract Separation on the AB-8 column (diameter-to-height ratio: 1:20), and the loading volume is 1:2. First rinse 2 column volumes with deionized water, then rinse 4 column volumes with 30% ethanol, collect the eluate, concentrate under reduced pressure at 60°C to a specific gravity of 1.10 to obtain a preliminary separation concentrate; the preliminary separation concentrate is put on the column MDS-5 (diameter-to-height ratio: 1:10), the loading volume is 1:1, rinse with deionized water for 3 column volumes, then rinse with 30% ethanol for 4 column volumes, collect 30% ethanol The washing solution was detected by thin layer chromatography, combined with the eluen...

Embodiment 3

[0024] Take 1Kg of dried safflower, extract twice with 30Kg deionized water, extraction temperature is 70°C, extraction time is 80min, the extracts are combined, filtered, and the filtrate is concentrated under reduced pressure at 60°C to a water extract with a specific gravity of about 1.12; H103 column separation (diameter-to-height ratio 1:20), sample loading 1:3. First rinse 4 column volumes with deionized water, then rinse 4 column volumes with 40% ethanol, collect the eluate, concentrate under reduced pressure at 60°C to a specific gravity of 1.10 to obtain a preliminary separation concentrate; the preliminary separation concentrate is put on the column MDS-5 (diameter-to-height ratio: 1:10), the loading volume is 2:1, rinse with deionized water for 3 column volumes, then rinse with 40% ethanol for 3 column volumes, collect 40% ethanol The washing solution was detected by thin layer chromatography, combined with the eluent containing hydroxysafflower yellow A spots, conc...

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PUM

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Abstract

A process for preparing hydroxyl carthamus tinctorius yellow color A comprises using dry carthanus tinctorius as raw material, using deionized water and water alcohol as extracting solution, passing through preliminary separating column and refining column, using deionized water and water alcohol as eluent, and then obtaining hydroxyl carthamus tinctorius yellow color A after frozen and dried, and the content can reach 85%-99%. The invention uses cheap material, no toxic and safe solution, and has simple technology, high carthamus tinctorius usage and low cost, which is suitable to the industrialized industry, and the extracting rate is 0.8%-1.5% according to different purify requests of hydroxyl carthamus tinctorius yellow color A for various applications.

Description

Technical field: [0001] The invention relates to a method for extracting active ingredients from medicinal plants, in particular to a preparation method for hydroxysafflower yellow A. Background technique: [0002] Safflower (Catthamus tinctotins L.) is an annual herb of Compositae, which has been cultivated and used for medicine for more than 2100 years in my country. Its dried tubular flowers are commonly used in traditional Chinese medicine, and have the effects of promoting blood circulation, removing blood stasis and relieving pain. It is often used clinically to treat uterine congestion, cardiovascular, thrombosis and other diseases, and also as an analgesic and anti-inflammatory agent. Hydroxysafflower yellow A is one of the currently recognized active ingredients of safflower. Pharmacological experiments have proved that hydroxysafflower yellow A can significantly improve hypoxia tolerance, dilate coronary arteries, increase coronary flow, and significantly inhibit ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/207C07H1/08C07D309/10A61K36/286
Inventor 张立伟贾俊贾菲菲
Owner 山西华卫药业有限公司
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