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Medicine compounds and applications in treating or preventing blood vessel inflammation medicine

A composition and drug technology, applied in the field of pharmaceutical composition and its application in the treatment or prevention of vascular inflammation drugs, can solve the problems of high recurrence rate and unclear pathogenesis

Inactive Publication Date: 2008-07-23
SHIHEZI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the cause of the disease is still unclear, the recurrence rate is high, there is no good clinical control and treatment method, and the high amputation rate is 28% [Research Progress of Thromboangiitis Obliterans in Traditional Chinese Medicine, Guo Yongyi et al., Henan Traditional Chinese Medicine Academic Journal, Volume 19, Issue 110, 2004]

Method used

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  • Medicine compounds and applications in treating or preventing blood vessel inflammation medicine
  • Medicine compounds and applications in treating or preventing blood vessel inflammation medicine
  • Medicine compounds and applications in treating or preventing blood vessel inflammation medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: Preparation of safflower total yellow pigment

[0017] The total safflower yellow was prepared according to the literature [Preparation of safflower yellow and hydroxyl safflower yellow A by macroporous resin column chromatography, Jin Ming et al., Chinese Herbal Medicine, Volume 35, Phase 1, 2004]. Safflower 5kg, add 50L of water, soak for 24 hours, and stir from time to time, filter out the extract; add 50L of water, soak for 24 hours, combine the extract, and centrifuge to remove the medicinal residue. Concentrate under reduced pressure below 80°C to 5L. Put the extract on D-4020 macroporous adsorption resin column (the volume ratio of extract and macroporous resin is 1:5), first elute with deionized water for 2 column volumes, and then deionized water for 5 columns Volume, eluate of 5 column volumes after collection, evaporated to dryness under reduced pressure below 80°C, and dried at constant temperature at 60°C to constant volume to obtain yellow-b...

Embodiment 2

[0018] Embodiment 2: Preparation of total flavonoids of licorice

[0019] The preparation method of the total flavonoids of licorice is prepared according to the method in the literature [Extraction, separation and determination of saponins and flavonoids in licorice, Gao Sulian et al., Journal of Anhui University, 2000, Vol. 24, No. 4;]. Take 3.0 kg of licorice rhizomes, dry them at room temperature, crush them (60 mesh), soak them in 95% ethanol at room temperature for 48 hours, 1.3 L each time, twice in total, combine the extracts, filter, and concentrate the filtrate in a water bath at 70°C under reduced pressure to form a thick paste After heating water and stirring to dissolve, it was extracted three times with petroleum ether and ethyl acetate successively. The ethyl acetate extract was extracted with 5% Na2CO3 aqueous solution, and the alkaline aqueous solution was adjusted to pH 5-6 with concentrated hydrochloric acid, then extracted with ethyl acetate, evaporated to ...

Embodiment 3

[0020] Embodiment 3: Preparation of safflower total yellow pigment licorice total flavonoids gel

[0021] Prescription composition: safflower total yellow pigment 20g

[0022] Total Licorice Flavonoids 20g

[0023] Ethanol 125g

[0024] Isopropanol 60g

[0025] Propylene glycol 28g

[0026] Azone 5g

[0027] Ethylparaben 0.2g

[0028] Carbomer 12g

[0029] Preparation method: Weigh 20.0g of safflower total yellow pigment, add 200ml of water, stir well, and dissolve.

[0030] Weigh 20.0 g of total licorice flavonoids, 5.0 g of azone, and 0.2 g of ethylparaben, and add 125 g of ethanol, 60 g of isopropanol and 28 g of propylene glycol to fully dissolve.

[0031] Weigh 12.0 g of carbomer, sprinkle it into 580 g of distilled water, adjust the pH value to 5.0-8.0 with triethanolamine after fully swelling, and then make the carbomer gel matrix.

[0032] Mix the above three solutions evenly, add distilled water to 1000g, stir evenly, and form a gel...

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Abstract

The invention pertains to the medicine technology field, which discloses a combination of gross safflor yellow which is safflower effective parts and total flavonoids of glycyrrhiza which is licorice effective parts and the application thereof. The invention is characterized in that the invention consists of gross safflor yellow, total flavonoids of glycyrrhiza and appropriate pharmaceutical excipients and is prepared into various formulations that are acceptable in pharmaceutics and have the effects of curing various vascular inflammation diseases, such as solid preparation, injection preparation and external gel, etc. Two effective parts in the invention are used together, which has distinctive synergy effect and has distinctive effects on diseases such as phlebitis caused by venipuncture, thrombophlebitis and thromboangiitis obliterans. Compared with the similar medicines of the market, the invention has the advantages of high security and better effect.

Description

technical field [0001] The invention relates to a pharmaceutical composition composed of safflower total yellow pigment and licorice total flavonoids, and also relates to its application in the preparation of medicines for treating or preventing venous inflammatory diseases caused by various reasons. Background technique [0002] The total yellow pigment of safflower is the effective part extracted from safflower. It is a mixed chalcone glycoside compound, which has various pharmacological effects such as expanding coronary arteries, lowering blood pressure, antithrombotic, hypoxia resistance, and immunosuppression. See [ An overview of modern research on safflower yellow, Wang Huiling, Chinese Traditional Chinese Medicine Science and Technology, Volume 5, Issue 5, 1998]. [0003] The total flavonoids of licorice is the effective part extracted from licorice, which has anti-tumor, anti-oxidation, antibacterial, anti-virus, anti-arrhythmia and myocardial ischemia, and treatme...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484A61K9/00A61K9/16A61K9/20A61K9/48A61P7/02A61P9/14
Inventor 王振华朱晔马成俊赵文彬张梅郑秋生
Owner SHIHEZI UNIVERSITY
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