Medicament for treating vascular dementia

A technology for vascular dementia and a drug, applied in the field of preparation thereof, can solve problems such as no research success, and achieve the effects of improving whole blood viscosity, increasing ratio, and increasing plasma cAMP level

Active Publication Date: 2008-08-20
GUANGZHOU BOJI MEDICINE SERVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] For the targeted treatment of Western medicine for vascular dementia, there are no reports of successful research at home and abroad

Method used

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  • Medicament for treating vascular dementia
  • Medicament for treating vascular dementia
  • Medicament for treating vascular dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0102] Take 27 parts of Earthworm, 27 parts of Epimedium, 15 parts of Rhizoma Chuanxiong, and 15 parts of Polygala (manufactured) (both parts by weight, the same below), add 65% ethanol aqueous solution to soak for 1.5 hours, extract twice, add 10 parts for the first time Extract with double the amount of ethanol for 2 hours, add 8 times the amount of ethanol for the second extraction for 1.5 hours, combine the extracts, recover the ethanol, concentrate to a relative density of 1.30-1.35 (60°C), vacuum-dry at 0.08MPa and 60°C, and pulverize Into a fine powder, set aside. Get 1.5 parts by weight of Ginkgo biloba extract fine powder and mix with the above-mentioned fine powder, add appropriate amount of microcrystalline cellulose and 3% crospovidone (PVPP), mix well, and mix with 2% povidone K 30 (PVP) made of 95% ethanol solution, extruded through a 16-mesh sieve, dried at 40-50°C, granulated, added 3% carboxymethyl starch sodium (CMS-Na) and 0.3% stearic acid The magnesium is...

Embodiment 2

[0104] Take 33 parts of Earthworm, 33 parts of Epimedium, 22 parts of Rhizoma Chuanxiong, and 22 parts of Polygala (manufactured), add 85% ethanol aqueous solution to soak for 1.5 hours, extract twice, add 5 times the amount of ethanol for 2 hours for the first time, and add 5 times the amount of ethanol for 2 hours for the second time Add 3 times the amount of ethanol for 1.5 hours, combine the extracts, recover ethanol, concentrate to a relative density of 1.30-1.35 (60°C), vacuum-dry at 0.08MPa and 60°C, grind into fine powder, and set aside. Get 5 parts by weight of Ginkgo biloba extract fine powder and mix with the above-mentioned fine powder, add appropriate amount of microcrystalline cellulose and 3% crospovidone (PVPP), mix evenly, and mix with 2% povidone K 30 (PVP) made of 95% ethanol solution, extruded through a 16-mesh sieve, dried at 40-50°C, granulated, added 3% carboxymethyl starch sodium (CMS-Na) and 0.3% stearic acid The magnesium is mixed evenly, compressed i...

Embodiment 3

[0106] Take 22 parts of Earthworm, 22 parts of Epimedium, 11 parts of Rhizoma Chuanxiong, and 11 parts of Polygala (manufactured), add 5 times the amount of 90% ethanol aqueous solution to soak for 3 hours, extract once, recover ethanol, concentrate to a relative density of 1.30-1.35 (60°C), vacuum-dried at 0.08MPa and 60°C, crushed into fine powder, and set aside. Get 10 parts by weight of Ginkgo biloba extract powder and mix it with the above-mentioned fine powder, add an appropriate amount of microcrystalline cellulose and 3% crospovidone (PVPP), mix well, and mix with 2% povidone K 30 (PVP) made of 95% ethanol solution, extruded through a 16-mesh sieve, dried at 40-50°C, granulated, added 3% carboxymethyl starch sodium (CMS-Na) and 0.3% stearic acid The magnesium is mixed evenly, compressed into tablets (0.40g / tablet), coated with film, and obtained.

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Abstract

The invention provides a medicine used to treat the vascular dementia with main symptoms of sputum blockage, blood stasis and deficiency of kidney and spermatozoa, as well as a method to prepare the medicine. The medicine in the invention is made of the following materials in weight proportions: 0.1-10 portions of ginkgo leaf extract, 22-37 portions of earthworm, 22-37 portions of epimedium, 11-25 portions of rhizoma ligustici wallichii, and 11-25 portionspolygala root.

Description

technical field [0001] The invention relates to a medicine containing ginkgo biloba extract for treating vascular dementia, a pharmaceutical composition containing it, and a preparation method thereof. Background technique [0002] With the aging of the world's population, the incidence of senile dementia has also increased greatly, and it has become one of the four major diseases that seriously threaten the health of the elderly. According to the survey, the incidence rate of vascular dementia increases linearly with age, and the annual incidence rate of the elderly over 65 years old is 1.2% to 4.2%. The average course of disease was 5 years, and the mortality rate was 25.7%. my country is the country with the largest elderly population in the world, and it is also one of the developing countries. Therefore, the research and development of safe, effective, quality-controllable, low-cost, and long-term convenient drugs for the treatment of vascular dementia has obvious soci...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/69A61P25/28A61K35/64A61K35/62
Inventor 张庆华
Owner GUANGZHOU BOJI MEDICINE SERVICES
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