Method for designing ribonucleic acid molecule with multiple steadiness structures

A ribonucleic acid, robust technology used in the field of computer programming

Inactive Publication Date: 2008-10-08
INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is still a huge challenge to design allosteric ribonucleic acid molecules that can fold into specified variable conformations, exhibit stable activity, possess robust and kinetic properties, and be triggered without the introduction of denaturation and annealing steps. challenge

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for designing ribonucleic acid molecule with multiple steadiness structures
  • Method for designing ribonucleic acid molecule with multiple steadiness structures
  • Method for designing ribonucleic acid molecule with multiple steadiness structures

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0037] figure 1 It is a general block diagram of a method for designing ribonucleic acid molecules with multiple robust structures of the present invention.

[0038] For each predetermined structure in the predetermined structure set input from the computer terminal, a legality check is performed according to the definition of the RNA secondary structure. RNA sequence R = r1 , r 2 ,...,r n is taken from the alphabet A string of where i=1, 2, . . . , n. The RNA secondary structure Ω is the set of all base pairs folded from the base pairs in the RNA sequence R, and the base pairs are composed of Any of six pairings are formed. Assume that i·j means that the i-th base r i and the jth base r j The base pairs formed where 1≤i

[0039] (1) For any base pair i·j in Ω, then

[0040] (2) For any two base pairs i 1 ·j 1 and j 2 ·j 2 , or i 1 = i 2 , j 1 = j 2 , or i 1 ≠ i 2 , i 1 ≠ j 2 , j 1...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a computer program, more specifically to a method for designing a RNA molecule having multi-robust structure. The invention aims to provide a method capable of designing a RNA molecule having multi-robust structure simply, conveniently and quickly, solves the design problem of allosteric RNA. The invention converts the design of a RNA molecule having multi-robust structure to the combinatorial optimization in a RNA molecule set comparable with a preset structure, uses a mathematical model based on graph theory, further converts the design to dependency graph vertex coloring, and proposes a method for designing a RNA molecule having multi-robust structure. The method comprises the steps of checking the validity of a set having preset structure inputted from a computer terminal, generating a dependency graph, checking the dichotomy of the dependency graph , decomposing the dependency graph, counting and uniformly sampling compatible sequences, selecting a cost function model and parameters, and optimizing candidate sequences.

Description

technical field [0001] The present invention relates to a computer program, more specifically, a method for designing ribonucleic acid molecules with multiple robust structures. Background technique [0002] There are ribonucleic acid molecules that form two or more metastable structures and have completely different functions, which are called ribonucleic acid molecular switches. The ribonucleic acid molecular switch regulates and controls various biological processes in nature. Its variable conformation is usually separated by a high energy barrier and can be triggered by ligand binding or external stimuli such as temperature changes. Experimental results show that there are many kinds of ribonucleic acid molecular switches with variable conformation and long life span in nature. [0003] Robustness is one of the most basic and common properties of biomacromolecules. It is understood as the ability of biomacromolecules to maintain stable functions in the face of various d...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/00G16B10/00
Inventor 王升启舒文杰伯晓晨
Owner INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap