Anticancer sustained-release gel injection containing platinum compound

Abstract

An anticancer sustained-release gel injection sustained-release microspheres containing platinum-based compound, amphiphilic block copolymer, solvent and release regulator, the mixture of amphiphilic block copolymer and solvent has a temperature sensitive gelatinization characteristic, and can automatically become non-flowing degradable water insoluble gel, which can locally and slowly release drug at tumor foci for several weeks to several months, after injection into body. The adjuvant in the sustained-release microspheres is poly(lactic acid)-glycollic acid copolymer; and the amphiphilic block copolymer is PLGA-PEG-PLGA copolymer. The preparation can be injected into artery, inside a tumor or around a tumor with remarkably reduced systemic toxicity of drug, and can be used for solid tumors at different stages. The platinum-based compound is selected from nedaplatin, carboplatin, cisplatin, enloplatin, ormaplatin, sulfato-1,2-diaminocyclohezane-platinum (SHP), picoplatin, cyclopentylamine platium, zeniplatin, spiroplatin, lobaplatin, iproplatin, oxaliplatin, cycloplatin, and dexormaplatin. The preparation can be used with radioactive particles and can enhance chemotherapy effect.

Description

A kind of anticancer slow-release gel injection containing platinum compounds (1) Technical field The invention relates to an anticancer slow-release gel injection containing platinum compounds, belonging to the technical field of medicines. Specifically, the invention relates to a slow-release gel preparation capable of stably releasing platinum compounds and / or slow-release microspheres in local solid tumors, mainly a slow-release gel injection. It is an aqueous solution, which can become a semi-solid or solid gel in the body of a warm-blooded animal, wherein the platinum compound is partially or completely encapsulated in the slow-release microspheres, and the platinum compound contained in the slow-release microspheres is slowly released in the local tumor. extended to several months. (2) Background technology Although there are many ways to treat cancer, the living conditions of most patients have not been significantly improved. Cancer has become the number one kil...

AI Technical Summary

Problems solved by technology

Therefore, in most cases, the final sustained-release formulations are mostly solid shapes (eg, microspheres, tablets, or rods), which require a more complicated implantation process, and are prone to tissue trauma and even tumor cell seeding or dissemination

Solid implants cannot effectively cover the irregular tumor cavity after tumor resection, so the residual tumor cells cannot be effectively remov...

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