Aqueous solution injection for picoplatin

A technology of meciplatin and injection, which is applied in the formulation field of the platinum group metal anti-tumor drug meciplatin, which can solve the problems of harm to the human body, unsuitable injection solvents, and inability to meet the clinical dosage requirements, etc., to solve the problem of dosage , the effect of improving solubility

Active Publication Date: 2011-09-21
KUNMING GUIYAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above solvents obviously cannot meet the clinical dosage requirements, and besides water, the other three solvents belong to Class II or Class III solvents in the classification of drug residual solvents, which will cause different degrees of harm to the human body, so they are not suitable as solvents for injections

Method used

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  • Aqueous solution injection for picoplatin

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Comparison scheme
Effect test

Embodiment Construction

[0014] This example is to illustrate the feasibility and stability of the formulation process of the present invention, but not to limit the present invention.

[0015] Embodiments 1-6 are as follows.

[0016] The 9‰ hydrochloric acid sodium chloride solution that chooses PEG400, pH value 2~3 below is solvent, and the embodiment result that obtains by above-mentioned operation method is as follows:

[0017]

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PUM

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Abstract

The invention provides picoplatin, which is a new generation of platinum group metal anti-tumor medicament with steric hinderance effect and is hardly dissolved in pure water, and relates to a preparation formula of the picoplatin (C6H10N2Pt). The injection is prepared by dissolving the picoplatin with mixed solution consisting of polyethylene glycol and solution of hydrochloride sodium chloride in a certain proportion serving as a solvent. The mixed solution obviously improves the dissolvability of the picoplatin up to 15mg / ml; and the injection has easy preparation, stable process and convenient clinical application, and is a perfect picoplatin preparation.

Description

technical field [0001] The invention belongs to the field of antineoplastic drugs, and relates to the preparation formula of the platinum group metal antineoplastic drug methidin. Background technique [0002] Methidine platinum is a platinum complex and is a new generation of platinum-based antineoplastic drugs after cisplatin, carboplatin and oxaliplatin. Picoplatin, also known as JM473, AMD473, ZD0473, etc., English name Picoplatin, full name cis-dichloro-ammonia, (2-picoline) platinum (II) [Cis-amminedichloro (2-picoline) platinum (II) ], molecular weight is 376.16, chemical structural formula: [0003] [0004] Methidine platinum was first jointly developed by Johnson Matthey Company of the United Kingdom, AnorMed Company of Canada and the British Institute of Cancer Research. It is a new type of platinum complex with steric hindrance effect. It shows good anti-tumor activity in vivo and in vitro. It started in 1997 It has entered the stage of clinical trial resear...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/555A61K47/34A61K47/02A61P35/00A61K47/10
Inventor 丛艳伟普绍平朱泽兵栾春芳贝玉祥缪祥宏
Owner KUNMING GUIYAN PHARMA
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