Microemulsion containing brucea javanica oil and preparation method thereof

A javanica javanica oil and microemulsion technology, which is applied in the field of medicine, can solve problems such as obvious toxicity and adverse reactions, low safety in the preparation process, and insufficient stability of preparations, and achieve good anticancer effects, good physical stability, and low cost Effect

Inactive Publication Date: 2008-10-22
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, javanica javanica oil is used in the preparation of anticancer drugs, the toxicity and adverse reactions are obvious, and the stability of the preparation is not enough. The microemulsion made generally cannot be sterilized by steam at 121 °C, and the safety of the preparation process is low. and high cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Each 100mL microemulsion contains 0.5g javanica javanica oil, 1g isopropyl myristate, 5g soybean lecithin, 5g poloxamer 188, 0.5g mannitol, and the rest is water for injection. The particle size distribution of the microemulsion is 10-100nm, and it is used for intravenous injection.

Embodiment 2

[0028] Each 100mL microemulsion contains 10g javanica javanica oil, 10g isopropyl myristate, 0.5g soybean lecithin, 10g Solutol HS 15, 5g sorbitol, glycerin, glucose, mannitol, and the rest is water for injection. The particle size distribution of the microemulsion is 10-100nm, and it is used for intravenous injection.

Embodiment 3

[0030] Each 100mL microemulsion contains 20g javanica javanica oil, 15g isopropyl myristate, 10g Solutol HS 15, 5g sorbitol, glycerin, glucose, mannitol, and the rest is water for injection. The microemulsion particle size ranges from 10 to 100nm and is used for intravenous injection.

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Abstract

The invention discloses a microemulsion containing fructus bruceae oil, 100ml of microemulsion comprises the following components: 0.5-20g of fructus bruceae oil, 1-15g of oil phase, 0.5-20g of emulsifier, 0.5-10g of auxiliary emulsifier, and water for injection for the rest. The invention also discloses a preparation method for the microemulsion, including the following procedures: the emulsifier and the auxiliary emulsifier are mixed up to be transparent, the fructus bruceae oil and the oil phase are mixed up, and then the two are mixed and emulsified, at last, water is filled for the margin, which is mixed into the finished product. The invention also discloses an application of the microemulsion in pharmacy, and the product is used for the preparation of intravenous anti-cancer drugs. The technological scheme of the invention improves the bioavailability and stability of microemulsion and pharmaceutical preparations in current technologies and better plays the role of anti-cancer of fructus bruceae oil.

Description

technical field [0001] The invention relates to a microemulsion containing javanica javanica and its preparation method and application, belonging to the technical field of medicine. Background technique [0002] Brucea javanica oil is a fatty oil extracted from the dried ripe fruit of the plant Bructus javanica of the family Bitterwoodaceae. It mainly contains 85% triolein and saturated or unsaturated fatty acids. The javanica javanica oil emulsion prepared with it can penetrate the blood-brain barrier, produce a higher concentration in the brain, and reduce intracranial pressure. Brucea javanica oil is not only used to treat various malignant tumors such as lung cancer, brain metastases of lung cancer, liver cancer, gastric cancer and breast cancer, but also can be used to treat non-tumor diseases such as chronic gastritis, colitis and genital warts. [0003] Polyethylene glycol stearate 15 (Solutol HS 15) is a polyethylene glycol (PEG) lithium lauryl hydroxystearate, wh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/107A61K47/14A61K47/24A61K47/26A61K47/34A61P35/00A61P1/04A61P1/00A61P31/14A61K131/00A61K47/10
Inventor 杨帆乔飞
Owner GUANGDONG PHARMA UNIV
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