Alcohol-containing polyhexamethylguanidine iodine disinfectant and preparation method thereof

A technology of polyhexamethylene guanidine and disinfectant, which is applied in the directions of non-active ingredients medical preparations, pharmaceutical formulations, topical antibacterial agents, etc. strong effect

Inactive Publication Date: 2008-11-26
SHANGHAI LIKANG DISINFECTION HIGH TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Polyhexamethylene guanidine alcohol solution has existing products at home and abroad, and Chinese Patent Publication N

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Add 3 grams of polyhexamethylene guanidine hydrochloride and 2 grams of iodine to 400 grams of 95% ethanol, heat and mix at 40°C for 2 hours, then add 5 grams of polyvinylpyrrolidone, 4 grams of azone, and 10 grams of glycerol. Mix 2 grams of 10% phosphoric acid and 574 grams of water to obtain the disinfectant.

Embodiment 2

[0038] Add 2 grams of polyhexamethylene guanidine hydrochloride and 4 grams of iodine to 500 grams of isopropanol, heat and mix at 60°C for 1 hour, then add 5 grams of polyvinylpyrrolidone, 4 grams of azone, and 10 grams of glycerol. 5 grams of 10% phosphoric acid, 470 grams of water, mix well to obtain the disinfectant.

Embodiment 3

[0040] Add 2 grams of polyhexamethylene biguanide hydrochloride and 3 grams of iodine to 400 grams of 95% ethanol, heat at 40°C for 3 hours, then add 10 grams of polyethylene glycol, 1 gram of dimethyl sulfoxide, and allantoin 10 grams, 3 grams of 10% phosphoric acid, 571 grams of water, and mix well to obtain the disinfectant.

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PUM

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Abstract

The invention relates to a disinfectant, in particular to the rapid skin disinfectant and a preparation method thereof. The alcohol-containing PHMG iodine disinfectant comprises components with the following percentages by weight: 0.05 to 2 percent of PHMG; 0.1 to 5 percent of iodine; 30 to 80 percent of alcohols; 0.1 to 2 percent of stabilizer; 0.1 to 1 percent of penetrating agent; 0.1 to 2 percent of skin care agent; 0.1 to 0.8 percent of phosphoric acid with the concentration of 10 percent and the rest of water. The preparation method of the alcohol-containing PHMG iodine disinfectant is that: the PHMG and the iodine are added in the alcohol according to the components and the contents of the disinfectant, the mixture is heated and mixed for 0.5 to 2 hours at the temperature of 30 to 70 DEG C, the stabilizer, the penetrating agent, the skin protective agent and the phosphoric acid of 10 percent are then respectively added, the water is finally added to 100 percent to be evenly mixed, and the disinfectant is obtained. The disinfectant has strong sterilization ability and very high stability, and the effective period is as long as two years, thus being the ideal rapid skin disinfectant.

Description

Technical field [0001] The invention relates to a disinfectant, in particular to a rapid skin disinfectant and a preparation method thereof. Background technique [0002] At present, the commonly used skin disinfectants at home and abroad are: [0003] Chlorhexidine alcohol disinfectant has been widely used in surgical hand disinfection and surgical site disinfection by the international medical community, and its clinical effects have proven strong sterilization performance. It is a disinfecting ingredient commonly used in skin disinfectants in countries all over the world. It is widely used internationally. The skin disinfectants produced by many multinational companies are still 0.5% chlorhexidine alcohol-based preparations, but the sterilization speed of such products is still Can not meet the needs of rapid disinfection of rescue patients, and can not indicate the disinfection area; [0004] Povidone-iodine aqueous solution is also widely produced and sold at home and abroad...

Claims

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Application Information

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IPC IPC(8): A61K33/18A61K47/10A61K47/22A61K47/34A61P31/02A61P17/00A61K31/785A61K47/32
Inventor 孙文胜张忠敏金锡奎黄春明
Owner SHANGHAI LIKANG DISINFECTION HIGH TECH
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