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New use of neuroregulation protein

A technology of neuregulin and its use, applied in the fields of biochemistry, molecular biology and medicine, can solve the problems that do not have about the role of neuregulin in heart rate regulation

Active Publication Date: 2014-04-16
ZENSUN (SHANGHAI) SCI & TECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] The prior art is silent on the role of neuregulin in heart rate regulation, nor on the effect of neuregulin on vagal nerve activity

Method used

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  • New use of neuroregulation protein
  • New use of neuroregulation protein
  • New use of neuroregulation protein

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0051] experimental method:

[0052] 1. Animal experiment methods

[0053] Recombinant human neuregulin (the 177-237 amino acid fragment of NRG1β2, Zesheng Technology Development Co., Ltd., batch number: 200503002) was chronically administered intravenously to adult mutt dogs, a total of 3, namely n=3, with a daily dose of 44.79U / kg (protein / body weight), administered for 6 days. The 12-lead electrocardiogram (ECG) was recorded on days 0, 1, 2, 4, 5, and 6 using an animal electrocardiograph. Repeat the above operation with a dose of 89.58U / kg. With excipient (10mM Na 2 HPO4-NaH 2 Two dogs treated with PO4, 150 mM NaCl, 0.2% HSA (human serum albumin), 5% mannitol, pH 6.0, dose of 4 ml / kg rat body weight) (corresponding to 89.58 U / kg neuregulin) were used as controls.

[0054] Chronic effects of neuregulin were examined 24 hours after each dose. Monitor for acute effects 10 minutes after the last dose.

[0055] 2. Experimental results:

[0056] 1) The effect of 44.79U / k...

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Abstract

The invention expands indications of a neuregulin in cardiovascular diseases, including sinus tachycardia and chronic atrial fibrillation. When the neuregulin is given to a mammal, the electrocardiogram PR interval thereof is found to be prolonged, and the heart rate is slowed down. The effect of slowing down the heart rate of the neuregulin can be used for anti-arrhythmias, and the chronic effect on the vagus nerve activity thereof can be used for treating sinus tachycardia and chronic atrial fibrillation.

Description

technical field [0001] The present invention relates to the fields of biochemistry, molecular biology and medicine. Specifically, the present invention relates to the indications of neuregulin in the treatment of cardiovascular diseases, including antiarrhythmia, sinus tachycardia and chronic atrial fibrillation. Background of the invention [0002] Neuregulin (NRG; heregulin, HRG), also known as glial growth factor (GGF), neu differentiation factor (new differentiation factor, NDF), is a glycoprotein with a molecular weight of about 44KD. It is a ligand for the ErbB family of tyrosine kinase receptors. The neuregulin family contains 4 members: NRG1, NRG2, NRG3, NRG4. (Falls et al., Exp Cell Res. 284:14-30, 2003) Relatively little is known about the biological functions of the latter three. NRG1 plays an important role in the nervous system, heart and breast, and there is also evidence that NRG1 signaling plays a role in the development, function and pathogenesis of sever...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/18A61P9/06
Inventor 周明东
Owner ZENSUN (SHANGHAI) SCI & TECH CO LTD
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