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Use of tiopronin in preparing medicament for treating liver function damage induced by cerebral ischemia, diabetes and obesity

A technology of tiopronin and cerebral ischemia is applied in the field of use of tiopronin in the preparation of medicines for the treatment of hepatic impairment secondary to cerebral ischemia, diabetes and obesity, and can solve the problem of lack of mechanism-specific treatment measures, etc.

Inactive Publication Date: 2010-09-29
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] For the cases of liver injury secondary to cerebral ischemia, obesity and diabetes, general non-specific hepatoprotective drugs are often used clinically, and there is a lack of specific treatment measures targeting the mechanism

Method used

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  • Use of tiopronin in preparing medicament for treating liver function damage induced by cerebral ischemia, diabetes and obesity
  • Use of tiopronin in preparing medicament for treating liver function damage induced by cerebral ischemia, diabetes and obesity
  • Use of tiopronin in preparing medicament for treating liver function damage induced by cerebral ischemia, diabetes and obesity

Examples

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Embodiment 1

[0024] Embodiment 1: the pharmaceutical composition of the present invention consists of 100 grams of tiopronin, 30 grams of carboxymethylcellulose, 20 grams of sucrose, 50 grams of medicinal starch (or select other pharmaceutically acceptable carriers and / or excipients such as Maltose, etc.), made into 1000 capsules. The preparation method is as follows: the mixture of tiopronin and pharmaceutically acceptable carriers and / or excipients is placed in the feed pot of a centrifugal coating granulator to form granules, and then filled with enteric-coated capsules, each capsule containing tiopronin 100mg.

Embodiment 2

[0025] Embodiment 2: The pharmaceutical composition of the present invention consists of 100 grams of tiopronin, plus 50 grams of maltose, or select other pharmaceutically acceptable carriers and / or excipients such as sucrose, fructose, etc., add water for injection to 1000ml, and pack into 1000 made. The preparation method is as follows: dissolve 100 grams of tiopronin and 50 grams of maltose in 1 liter of water for injection, fully stir and dissolve, add 0.01 to 0.1% activated carbon for injection to absorb pyrogens, filter to remove activated carbon, and positive pressure microporous filtration to sterilize , subpackaged, each containing 100mg tiopronin.

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Abstract

The invention relates to tiopronin or medical new use of the sodium salt thereof, in particular to the application of the tiopronin or the sodium salt thereof in the preparation of medicine for treating liver functional damage caused by cerebral ischemia, diabetes and obesity. The tiopronin has the function of specifically inhibiting liver cytochrome P450 2E1 (CYP2E1), there protecting the liver function from being damaged caused by cerebral ischemia, diabetes and obesity, so as to be a new clinical use having direction. The new use further expands the medical value of the tiopronin, which istaken as an inhibitor of liver CYP2E1 for protecting the function of liver, thus having important medical value, social and economic benefits.

Description

1. Technical field [0001] The invention relates to the use of tiopronin as a cytochrome P4502E1 (CYP2E1) inhibitor in the preparation of medicines for treating liver function damage secondary to cerebral ischemia, obesity and diabetes. 2. Background technology [0002] Tiopronin (English name Tiopronin, chemical name: mercaptopropionylglycine), its molecular formula: C 5 h 9 NO 3 SH, molecular weight: 163.2, structural formula as follows: [0003] [0004] The liver is the main organ for the transformation and metabolism of various substances in the body. It expresses a variety of enzyme systems involved in the metabolism of substances, the most important of which is cytochrome P450 (CYPs for short). CYPs is a superfamily enzyme system with multiple subtypes, which metabolizes a variety of endogenous substances (substances synthesized by the body's own metabolism) and exogenous substances (including drugs, environmental toxicants, etc.), and is mainly expressed in the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/195A61P9/10A61P3/10A61P3/06A61P1/16
Inventor 彭仁琇乐江
Owner WUHAN UNIV
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