Senile dementia recombinant adenovirus gene vaccine and preparation method thereof

A technology of recombinant adenovirus and gene vaccine, which is applied in the field of vaccines and its preparation, can solve the problems of unfavorable B cell antigen epitope exposure, difficulty in chemical modification of synthetic peptides, and influence on the spatial structure of antigens, so as to avoid high difficulty and high cost , enhance immunogenicity, and avoid the effects of spatial rigidity
CN101357227BActive Publication Date: 2011-07-27LIVZON PHARM GRP INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
LIVZON PHARM GRP INC
Publication Date
2011-07-27

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Abstract

The invention discloses senile dementia Ad-GFP gene vaccine and a preparation method thereof and is Ad-GFP vaccine of flexible foldable multivalence Beta- amyloid 1-15 (ABeta1-15) of secretion co-expression and genetic adjuvant, which a flexible connecting peptide is used for connecting multivalence. The invention selects foldable multivalence ABeta1-15 as immunogen, which avoids the space rigid structure of multiple copy ABetaB cell epitopes, also ensures that ABeta15 epitopes are more easily exposed, thus enhancing immunogenicity and also increasing immunogenic molecular weight and reducing the possibility of degradation; a antigen delivery system that takes adenovirus as a carrier is selected, which avoids the defects of high challenge and high cost of chemosynthesis.
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Description

technical field

[0001] The invention relates to a vaccine and a preparation method thereof, in particular to a recombinant multivalent β-amyloid 1-15 (Aβ) for senile dementia 1-15 ) adenovirus vaccine and its preparation method. Background technique

[0002] Alzheimer's disease (AD) is a neurodegenerative disease characterized clinically by progressive memory and loss of acquired knowledge until the patient loses the ability to live. With the increase of the number of cases, AD brings a heavy burden to the family and society, and is an important social and medical health problem. Regarding the treatment of AD, there is no ideal method at present. The existing treatment strategies mainly focus on relieving symptoms, but do not prevent the pathological process of AD, and their clinical efficacy is not satisfactory. Aβ is the main component of senile plaques in the pathological changes of senile dementia, which consists of 39-42 amino acids. Recent studies have shown that th...

Claims

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