30results about How to "Reduce the possibility of degradation" patented technology

An enamel-plastics powder for the meter panel of car is prepared from polyvinyl chloride resin, non-toxic stabilizer, high-molecular plasticizer and superfine polyvinyl chloride resin through proportional mixing. Its advantages include high flowability, excellent melting performance and good mechanical performance.

Disclosed are water soluble polymeric reagents comprising the structure POLY-[Y—S—W]x, where POLY is a water soluble polymer; Y is a hydrocarbon-based spacer group, x is 1 to 25, and S—W is a thiol, protected thiol, or thiol-reactive derivative. Preferably, the water soluble polymer is a PEG polymer. Also disclosed are conjugates of such polymeric reagents with pharmaceutically relevant molecules, and methods of their formation and use.

Disclosed are water soluble polymeric reagents comprising the structure POLY-[Y—S—W]x, where POLY is a water soluble polymer; Y is a hydrocarbon-based spacer group, x is 1 to 25, and S—W is a thiol, protected thiol, or thiol-reactive derivative. Preferably, the water soluble polymer is a PEG polymer. Also disclosed are conjugates of such polymeric reagents with pharmaceutically relevant molecules, and methods of their formation and use.

Various embodiments relating to detection of an end-stop position of a waste gate valve and calibration of a waste gate position sensor relative to the detected end-stop position are provided. In this way, it is possible to more accurately control the waste gate.

The invention relates to a recombinant multivalent Beta-amyloid 1-15(ABeta1-15) protein vaccine of senile dementia and a preparation method thereof. The proposal is adopted as following: a plurality of oligonucleotide primers are synthesized, two or more than two bivalent ABeta1-15 gene sections containing flexion connection peptide gene are obtained by gene amplification and are cloned into pQE-30 prokaryotic expression plasmid, and inducible expression by bacillus and purification are carried out, thus preparing the folding bivalent ABeta1-15 recombinant protein vaccine which can express flexibility. In the invention, the multivalent folding ABeta1-15 is selected as the immunogen, thus avoiding the spacing rigescent structure of multi-copy ABetaB cell epitope, leading the ABeta1-15 epitope to be exposed easily, and improving immunogenicity. Meanwhile, the molecular weight of immunogenicity is increased, and the possibility of degradation is lowered. The prokaryotic expression system is selected for preparing recombinant protein, thus avoiding the shortcomings of high difficulty and high cost of chemosynthesis.

The invention discloses a lipid nanoparticle for inhibiting antisense oligonucleotide of bcl-2, and belongs to the field of bio-technology. The lipid nanoparticle for inhibiting the antisense oligonucleotide of bcl-2 is prepared by covering a section of antisense oligonucleotide by virtue of a membrane material, wherein the nucleotide sequence of the lipid nanoparticle is 5'-TCTCCCAGCGTGCGCCAT-3'or 5'-UCUCCCAGCGTGCGCCAU-3'. The invention also discloses a preparation method of the lipid nanoparticle. The nanoparticle provided by the invention can take a good blocking effect on the growth of tumor cells and specific target genes, and especially for KB cervical cancer cells.

The invention discloses a lipid nanoparticle membrane material composition. The membrane material composition consists of cationic lipids, neutral phospholipid, cholesterol, Tween and a polyethylene glycol derivative, wherein the molar ratio of the cationic lipids to the neutral phospholipid to the cholesterol to the Tween to the polyethylene glycol derivative in the membrane material compositionis at (25-35) to (40-50) to (15-25) to (1-5) to (1-5). Meanwhile, the invention also provides a method for preparing lipid nanoparticles by virtue of the lipid nanoparticle membrane material composition. The lipid nanoparticle membrane material composition provided by the invention can improve the stability of the lipid nanoparticles, and subsequently promote the release of drugs in tumor tissuesand reduce the possibility of being degraded.

The present invention provides a heating device capable of dispensing heated personal care product while containers thereof are being heated. For example, there could be a base having multiple wells with a heating system associated with each well. There could be separate control of the heat in each well. The wells have an upper opening for permitting insertion of a container in them (in inverted fashion), and a side opening for permitting heated material in a container to be dispensed from the container while a portion of the container is being heated in the well. In another form, the invention provides a temperature sensor at the bottom of a heating well that projects into a heat conductive head of a container being warmed in the well. Methods for using such devices are also disclosed.

An enamel-plastics powder for the meter panel of car is prepared from polyvinyl chloride resin, non-toxic stabilizer, high-molecular plasticizer and superfine polyvinyl chloride resin through proportional mixing. Its advantages include high flowability, excellent melting performance and good mechanical performance.

The embodiment of the invention provides a halogen-free flame-retardant high-density polyethylene material and a preparation method and application thereof. According to the halogen-free flame-retardant high-density polyethylene material, the flame-retardant property UL94 reaches a V-2 level, the mechanical property is excellent, and the elongation at break of a workpiece reaches 842%; the material can be recycled, is environment-friendly and halogen-free, does not generate corrosive gases during combustion and has excellent self-extinguishment; and the problem that in the prior art, a halogen-free flame-retardant technology of HDPE has an environment-friendly problem in mechanical property and bromine-antimony flame retarding is solved.

Systems and methods for operating an electric energy storage system are described. The systems and methods include ways of coupling electric energy storage cell stacks to an electric conductor or bus. The coupling is performed to reduce current flow through contactors and to increase a life span of the contactors.

The invention discloses a method of efficiently extracting quorum sensing signal molecules from aerobic granular sludge. The method can efficiently extract quorum sensing signal molecules from extracellular polymeric substances in aerobic granular sludge. The method comprises the following steps: (1) extracellular polymeric substance hydrolysis; (2) hydrolysis supernate collection; (3) liquid-liquid extraction; (4) vacuum concentration; and (5) nitrogen blowing and constant volume. The operation is convenient, and the reaction conditions are mild. The method can solve the problem of single molecular decomposition caused by release of intracellular organic matters during the process of extracting signal molecules from a granular sludge system and is an efficient and feasible signal molecule extraction method.

Systems and methods for operating an engine that includes a cavity in an exhaust manifold of a turbocharged engine are described. The systems and methods may improve engine efficiency and provide a way of controlling temperatures of engine exhaust components. The cavity may be located between an exterior wall of the exhaust manifold and an interior wall of the exhaust manifold.

The application relates to the field of TPE particles, and specifically discloses an aging-resistant TPE particle and a preparation method thereof. An aging-resistant TPE particle is made of raw materials comprising the following parts by weight: a base material mixed with SBS and SEBS; rubber oil; oil-locking additive; filler; toner; antioxidant; anti-aging additive; its preparation The method is as follows: mix the base material with rubber oil, stir evenly and let it stand for 30-60 minutes to obtain a first-class mixture; put oil-locking additives, fillers, toner, antioxidants and anti-aging additives into the first-class mixture, mix homogeneously to obtain a secondary mixture; extrude, pelletize, and dry to obtain TPE pellets. The anti-aging TPE granules of the present application have better aging resistance and longer service life; in addition, the preparation method of the present application is simple to operate, can promote the full reaction of each raw material component, and ensures that the TPE granules have better anti-aging performance.

The invention relates to polymers / gold nanoparticles complex medium for DNA sequencing with capillary electrophoresis and its preparation method, and belongs to the biotechnological field of DNA sequencing and separation. The concentration of the buffer solution of polymers / gold nanoparticles complex medium used for DNA sequencing is 2.0%-3.0%. The invention comprises the steps of: (1) synthesis of quasi-interpenetrating polymer networks with self-spreading ability, (2) preparation of Au nanoparticles, and (3) synthesis of complex medium of quasi-interpenetrating polymer networks / gold nanoparticles. The complex medium with reduced viscosity at proper concentration is easy to be pumped into and run out of the capillaries, and can prevent the production of electroosmotic flow because of theexistence of complex with self spreading ability, which saves the step of spreading inner wall of the capillary, simplifies the preparation process of column, reduces the application cost of capillary, elongates the service time of capillary. The invention is mainly used for separating DNA with capillary electrophoresis and DNA sequencing.

The invention discloses a preparation method for diamine polydactyl acid, comprising the steps of: reacting unsaturated amic acid having a general formula shown below (wherein R is unsaturated alkyl or aryl and n is any integer from 2 to 6) with amido protecting agent to prepare the amido-protecting unsaturated amic acid, performing free radical graft copolymerization reaction on polylactic acid, amido-protecting unsaturated amic acid and radical initiator to prepare the amido-protecting unsaturated amic polydactyl acid, and performing amido de-protection on unsaturated amic polydactyl acid to acquire the diamine polydactyl acid. Compared with the prior art, the method of the invention avoids polylactic acid directly contacting with basic amino and less polylactic acid participates in reaction, so the degradability of polylactic acid main chain is greatly decreased and the acquired diamine polydactyl acid has better mechanical property.

The present invention provides a heating device capable of dispensing heated personal care product while containers thereof are being heated. For example, there could be a base having multiple wells with a heating system associated with each well. There could be separate control of the heat in each well. The wells have an upper opening for permitting insertion of a container in them (in inverted fashion), and a side opening for permitting heated material in a container to be dispensed from the container while a portion of the container is being heated in the well. In another form, the invention provides a temperature sensor at the bottom of a heating well that projects into a heat conductive head of a container being warmed in the well. Methods for using such devices are also disclosed.

The invention relates to a preparation method of a grafted crosslinked polyamide lining pipe material and a high-temperature-resistant lining oil extraction pipe, and discloses a lining pipe material of a high-temperature-resistant lining oil extraction pipe. The lining pipe material of the high-temperature-resistant lining oil extraction pipe is prepared from the following components in parts by weight: 20-25 parts of polyhexamethylene adipamide, 1-10 parts of ethylene-propylene-diene-terpolymer rubber, 1-10 parts of grafted polyolefin elastomer, 5-15 parts of N,N'-m-phenylene bismaleimide, 1-5 parts of antioxidant, 1-5 parts of anti-ageing agent, 0.1-0.8 part of cross-linking agent and 0.015-0.05 part of grafting catalyst. The lining pipe material of the high-temperature-resistant lining oil extraction pipe has the advantages of being high-temperature-resistant, wear-resistant, corrosion-resistant and wax-resistant, and can be used in an oil extraction well at the temperature of more than 150 DEG C for a long term.

The invention relates to ultraviolet-aging-resistant polyphenylene sulfide fibers and a preparation method thereof. The polyphenylene sulfide fibers comprise the following components in parts by weight: 100 parts of polyphenylene sulfide, 0.2-5 parts of 2-(3-N,N-diethyl-phenyl)amino-4,6-bis(4-tert-butyl-2-hydroxyphenyl)-sym-triazine and 0.2-5 parts of 2-ethylene imine-4-(2,2-dimethyl-4-tert-butyl)phenyl-6-(4-tert-butyl-2-hydroxy)-phenyl-triazine; and the fineness of the fibers is 1.2-6.6 dtex. The preparation method provided by the invention comprises the following steps of: adding polyphenylene sulfide, 2-(3-N,N-diethyl-phenyl)amino-4,6-bis(4-tert-butyl-2-hydroxyphenyl)-sym-triazine and 2-ethylene imine-4-(2,2-dimethyl-4-tert-butyl)phenyl-6-(4-tert-butyl-2-hydroxy)-phenyl-triazine to a screw spinning machine according to the proportions, carrying out melt spinning to obtain crude polyphenylene sulfide fibers, and then drawing and treating to obtain the fibers. The obtained fibers have greatly improved strength and modulus and excellent ultraviolet aging resistance.

An integrated device for sample extraction, purification and concentration, including a solvent system, a sample extraction system, a sample purification system, a sample concentration system and a computer; wherein: the solvent system provides necessary solvents for the sample extraction and purification steps; the sample extraction system adopts advanced After pre-freezing the sample with liquid nitrogen, the method of organic solvent extraction is carried out. The extract is stored in the buffer pool and injected into the sample purification system by high-purity nitrogen. The sample purification system includes acid silica gel column, composite silica gel column, alumina column, Commercial packed columns such as activated carbon columns can be used for single-column and multi-column series purification; the sample concentration system uses the heat generated by resonance of nano-gold or nano-silver particles to evaporate and concentrate the sample solution, and the concentrated solution is transferred to the sample receiving bottle. Sample pretreatment process.

The invention discloses senile dementia Ad-GFP gene vaccine and a preparation method thereof and is Ad-GFP vaccine of flexible foldable multivalence Beta- amyloid 1-15 (ABeta1-15) of secretion co-expression and genetic adjuvant, which a flexible connecting peptide is used for connecting multivalence. The invention selects foldable multivalence ABeta1-15 as immunogen, which avoids the space rigid structure of multiple copy ABetaB cell epitopes, also ensures that ABeta15 epitopes are more easily exposed, thus enhancing immunogenicity and also increasing immunogenic molecular weight and reducing the possibility of degradation; a antigen delivery system that takes adenovirus as a carrier is selected, which avoids the defects of high challenge and high cost of chemosynthesis.

The invention mainly provides a method for highly expressing antimicrobial peptides in yeast. The method provided by the present invention comprises the fusion expression of an antimicrobial peptide and a red fluorescent protein, and in the recombinant yeast, the level of antimicrobial peptide production in the strain can be judged by the color depth visible to the naked eye, so as to quickly screen out highly expressed antimicrobial peptides and Engineering strains with strong antibacterial activity. The invention also provides a recombinant fusion protein with antibacterial activity and engineering recombinant bacteria, which can be directly applied in industry or feed industry.