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Preparation of total saponins of Thelenota ananas and application thereof in medicine field

A technology of plum flower ginseng and total saponins, which is applied in the field of medicine, can solve the problems of few researches on the preparation method of plum flower ginseng total saponins, and achieve the effect of remarkable drug effect, large processing capacity and strong controllability

Inactive Publication Date: 2009-03-04
宁波保税区欣诺生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The existing literature is mainly about the extraction process and content determination of plum flower ginseng polysaccharides in plum flower ginseng, and there are few studies on the preparation method of plum flower ginseng total saponins

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Wash 10 kilograms of Plum Blossom Ginseng, chop it, and soak it in turn with 5 times the amount (weight) of 95%, 85%, and 85% ethanol respectively, soak for 7 days each time, combine the ethanol leaching solution, reclaim ethanol under reduced pressure, and obtain a stream. extract. Dissolve the liquid extract in 3 times the amount of water, filter, and pass the filtrate through a DA201-B macroporous resin column, elute with water and 50% ethanol in sequence, collect the 50% ethanol eluate, recover ethanol under reduced pressure until dryness, and obtain total saponins 55 grams.

Embodiment 2

[0018] Take 20 g of total saponins of plum flower ginseng, disperse with appropriate amount of water for injection, add appropriate amount of excipients, mix well, make granules, and dry.

[0019] The granules obtained according to the examples are divided into empty capsules according to the required dosage to obtain capsules.

[0020] The granules obtained according to the examples were directly compressed and film-coated to obtain tablets.

[0021] For the treatment of tumor diseases.

Embodiment 3

[0023] The total saponins of plum flower ginseng are dispersed by adding water for injection in an appropriate amount, and spray-dried or vacuum-dried to obtain the total glycosides of plum flower ginseng dry powder. Take polyethylene glycol 400, add plum flower ginseng total saponin dry powder, stir until uniform while adding, adopt compression method, and make soft capsule. For the treatment of tumor diseases.

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PUM

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Abstract

The invention relates to the pharmaceutical technical field, in particular to a compound of thelenota ananas total saponins extracted from thelenota ananas. The invention further provides a preparation method and a use of the thelenota ananas total saponins. The compound has low cost of extract of the thelenota ananas, strong controllability and stable quality.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a total saponin compound extracted from plum flower ginseng as a raw material, including a preparation method and application of the extract. Background technique [0002] Plum ginseng (Thelenota ananas J), also known as "pineapple ginseng", is an animal of the sea cucumber class Aposticidae of the marine echinodermata. Its body is very large, generally 700mm long, 100mm wide, and 80mm high. It is widely distributed in Xisha, my country. The archipelago and the southern tip of Taiwan have the effects of nourishing liver and kidney, benefiting essence and nourishing blood. [0003] Saponin is one of the main secondary metabolites of Prunella ginseng, the main material basis of its chemical defense, and has various biological activities such as antifungal, anticoagulant, immune regulation, cytotoxicity and antiviral. In the in vitro cytotoxic activity screening, it was found that th...

Claims

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Application Information

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IPC IPC(8): A61K35/56A61P35/00A61K35/616
Inventor 巫军
Owner 宁波保税区欣诺生物技术有限公司
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