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A pH sensitive solid medicine composition for oral liquid and preparation method thereof

A composition and sensitive technology, applied in drug combination, drug delivery, anti-infective drugs, etc., can solve problems such as limited, long-term stability of nanoparticles to be solved, complex industrialization of preparation methods, etc.

Active Publication Date: 2009-03-11
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Including the limited selection of pharmaceutical carrier materials (for drug-loaded nanoparticles), the industrialization of the preparation method is relatively complicated, the long-term stability of nanoparticles needs to be solved, and the safety issues of polymer materials and surfactants need to be solved. Evaluation, higher cost of preparation, etc.

Method used

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  • A pH sensitive solid medicine composition for oral liquid and preparation method thereof
  • A pH sensitive solid medicine composition for oral liquid and preparation method thereof
  • A pH sensitive solid medicine composition for oral liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0112] Embodiment 1: the preparation of solid pharmaceutical composition

[0113] Weigh 1g of Eudragit S100, fully disperse and dissolve it in an appropriate amount of absolute ethanol to form a uniform solution, weigh 0.2g of cyclosporine A, and dissolve it in the above solution; take 1.2g of Aerosil 200 and mix with the above solution to make the liquid Fully adsorbed; the container containing the above mixture was placed in a vacuum desiccator, and the solvent was removed under reduced pressure to form a white blocky solid. Take it out, smash it, sieve it, and get it.

Embodiment 2

[0114] Embodiment 2: the preparation of solid pharmaceutical composition

[0115] Weigh 100mg of Eudragit S100, fully disperse and dissolve in absolute ethanol to form a homogeneous solution, weigh 20mg of Tacomus (FK506), and dissolve in the solution; take 120mg of Aerosil 300 powder without mixing with the above solution, make The liquid was fully absorbed; the container containing the mixture was placed in a vacuum desiccator, and the solvent was removed under reduced pressure to form a white blocky solid. Take it out, smash it, sieve it, and get it.

Embodiment 3

[0116] Embodiment 3: the preparation of solid pharmaceutical composition

[0117] Weigh 100mg of Eudragit S100, fully disperse and dissolve in absolute ethanol to form a homogeneous solution, weigh 20mg of sirolimus, and dissolve in the solution; take 120mg of Cab-O-Sil H5 and mix with the above solution to make the liquid Fully adsorbed; the container containing the mixture was placed in a vacuum desiccator, and the solvent was removed under reduced pressure to form a white blocky solid. Take it out, smash it, sieve it, and get it.

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Abstract

The invention relates to a pH sensitivity solid drug composite used for oral preparations and a preparation method thereof. Drug release of the solid drug composite in a gastrointestinal tract has the pH sensitivity, and the solid drug composite can enhance the absorption of drugs in the gastrointestinal tract or improve other performances of the drugs.

Description

technical field [0001] The invention relates to a nano-medicine technology, in particular to a pH-sensitive solid pharmaceutical composition for oral preparations and a preparation method. The drug release of the solid pharmaceutical composition in the gastrointestinal tract has pH sensitivity, and the solid pharmaceutical composition can increase the absorption of the drug in the gastrointestinal tract or improve other properties of the drug. Background technique [0002] Oral absorption of drugs has always been a very important aspect in pharmaceutical formulations. Oral administration of drugs is the most widely used route of administration in clinical practice due to its good compliance. According to reports, 40% of the drugs have solubility problems, and insoluble means poor absorption; another considerable number of new drugs encounter malabsorption problems during the development process, which can directly determine whether they can become new drugs in many cases. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/38A61K47/34A61K47/04A61K9/00
CPCA61K9/1652A61K9/4866A61K9/146A61K9/4858A61K9/2077A61K9/143A61K9/1635A61P9/00A61P31/00A61P37/06
Inventor 张强王坚成郭宇岚
Owner PEKING UNIV
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