Uses of medicament composition in preparing medicament for improving brain microcirculation disorder

A technology of microcirculation disorder and composition, which is applied in the field of medicine and can solve problems such as no improvement effect reported

Active Publication Date: 2009-05-13
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on whether Yangxue Xuenao Granules can improve the cerebral microcirculation disorder caused by ischemia-reperfusion.

Method used

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  • Uses of medicament composition in preparing medicament for improving brain microcirculation disorder
  • Uses of medicament composition in preparing medicament for improving brain microcirculation disorder
  • Uses of medicament composition in preparing medicament for improving brain microcirculation disorder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0151] Embodiment one pharmaceutical composition preparation

[0152] (1) Take 67.5g of Angelica, 67.5g of Chuanxiong, 54g of Radix Paeoniae Alba, 54g of Rehmannia Rehmanniae, 135g of Spatholobus Spatholobus, 135g of Prunella vulgaris, 135g of Cassia Seed, 135g of Mother of Pearl, 67.5g of Rhizoma Rhizoma Rhizoma, 14.5g of Asarum;

[0153] (2) Add water to extract the above medicinal materials 3 times, each time for 1 hour, combine the extracts, concentrate appropriately, add 2 times the amount of ethanol, let stand for 24 hours to precipitate, take the supernatant and concentrate it into an extract, with a relative density of 1.4, The paste yield is 10%. Take clear paste, sucrose and dextrin at a ratio of 1:3:1 to make 125 bags of granules.

Embodiment 2

[0154] Embodiment two pharmaceutical composition formulations

[0155] (1) Take 80g of Angelica, 80g of Chuanxiong, 80g of Paeoniae Alba, 80g of Rehmannia Rehmanniae, 120g of Uncle Teng, 120g of Spatholobus, 120g of Prunella vulgaris, 120g of Cassia Seed, 120g of Mother of Pearl, 70g of Rhizoma Rhizoma Rhizoma, 10g of Asarum;

[0156] (2) Add water to extract the above medicinal materials 3 times, each time for 1 hour, combine the extracts, concentrate appropriately, add 2 times the amount of ethanol, let stand for 24 hours to precipitate, take the supernatant and concentrate into an extract, the relative density is 1.3, The paste yield is 10%. Take clear paste, sucrose and dextrin at a ratio of 1:3:1 to make 200 tablets.

Embodiment 3

[0157] Embodiment three Chinese medicine composition preparation

[0158] (1) Take 40g of Angelica, 40g of Chuanxiong, 20g of Paeoniae Alba, 20g of Rehmannia Rehmanniae, 100g of Uncle Teng, 100g of Caulis Spatholobus, 100g of Prunella vulgaris, 100g of Cassia Seed, 100g of Mother of Pearl, 70g of Rhizoma Rhizoma Rhizoma, 10g of Asarum;

[0159] (2) Add water to extract the above medicinal materials 3 times, each time for 1 hour, combine the extracts, concentrate appropriately, add 2 times the amount of ethanol, let stand for 24 hours to precipitate, take the supernatant and concentrate into an extract, the relative density is 1.3, The paste yield is 10%. Take clear paste, sucrose and dextrin at a ratio of 1:3:1 to make 100 capsules.

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Abstract

The invention provides an application of a pharmaceutical composition in the preparation of drugs for improving cerebral microcirculation dysfunction. The application uses an ischemia-reperfusion model which is established by the ligation of bilateral carotid arteries of a Mongolian gerbil, the dynamic cerebral microcirculation including cerebral blood flow, blood velocity, blood vessel diameter, generation of vascular endothelial peroxides, leukocyte adhesion and change of vascular permeability of the Mongolian gerbil is observed through a visual dynamic continuous system after the ligation of the bilateral carotid arteries, and a projecting and scanning electron microscope is further used for observing the changes of ultrastructures of small veins and capillaries for observation and research, thereby proving that Yangxueqingnao particles have the effects of treating and improving the cerebral microcirculation dysfunction caused by ischemia-reperfusion.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of Yangxueqingnao Granules in the preparation of drugs for improving microcirculation disorders. Background technique [0002] The average incidence rate of cerebrovascular diseases in the world is 140-200 / 100,000 population, and the average death rate is 100 / 100,000 population, which is a disease with high morbidity and mortality. Improving cerebrovascular injury is of great significance to saving lives and reducing medical costs. Cerebrovascular injury caused by ischemia-reperfusion accounts for about 60% of the causes of cerebrovascular injury. The peroxide produced after ischemia-reperfusion degrades I-κB, activates NF-κB, and the subunit of NF-κB enters the nucleus, activates adhesion molecules, inflammatory factors and apoptosis-related gene sites, and promotes the formation of adhesion molecules. Expression, release of inflammatory cytokines and initia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K9/16A61P9/10A61K35/56A61K35/618
Inventor 韩晶岩徐想顺刘育英胡白和王芳赵新荣常昕安丽华孙凯王传社
Owner TIANJIN TASLY PHARMA CO LTD
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