Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Therapeutic compositions containing amlodipine and niacin medicament

A kind of technology of amlodipine and composition, applied in the field of patients with cardiac risk symptoms, can solve the problems of increasing HDL-C, insufficient, unable to comprehensively reduce the risk factors of hyperlipidemia and the like

Inactive Publication Date: 2009-05-20
BEIJING ROCK PHARMA
View PDF4 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The amlodipine and atorvastatin composition realizes dual control of hypertension and hyperlipidemia, can control coronary heart disease, atherosclerosis, and two risk spectrums of angina pectoris, thereby reducing coronary heart disease, atherosclerosis Hardening, and the occurrence of angina pectoris, however, coronary heart disease is caused by multiple factors, and it is still not enough to control the two risk factors, and the adovastatin in the composition can effectively reduce LDL-C, but it can increase HDL -C is not obvious, and cannot reduce the level of Lp(a), another independent risk factor for coronary heart disease, and cannot comprehensively reduce the risk factors of hyperlipidemia

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Therapeutic compositions containing amlodipine and niacin medicament
  • Therapeutic compositions containing amlodipine and niacin medicament
  • Therapeutic compositions containing amlodipine and niacin medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1 The composition has the effect of lowering blood pressure and blood fat in hypertensive and hyperlipidemia mammals.

[0049] Establishment of animal model of hypertension with hyperlipidemia

[0050] Adopt the big gray rat that the white rat and the house mouse crossbreed (it is easier to induce success than the purebred white rat), 4 months old, feed and take 10% protein yellow powder, 5% lard, 0.5% bile salt, 85% basal feed, Put them into cages in a soundproof room, and the noise stimulation can be issued by an electric bell or a loudspeaker. The sound generator is an audio oscillator connected to a 20W tweeter. The noise stimulation should be changed frequently at 700-1000 cycles / second, and the noise stimulation can be done once every 30 seconds, or every 1 minute for 30 seconds. It can be changed at any time and does not need to be constant, but the noise disturbance must continue day and night for several months. After noise stimulation for 3 consecuti...

Embodiment 2

[0060] Example 2 The therapeutic effect of the composition on mammalian (including human) atherosclerosis.

[0061] Animal model construction of atherosclerosis

[0062] Rabbit induction model: select Japanese white rabbits, weighing about 2kg, fed with 1g of cholesterol per day, aortic atherosclerotic plaques can be seen with the naked eye after 2 months; the incidence of aortic plaques is 100%, and serum cholesterol can grow up to 540mg / dl.

[0063] Grouping: 40 white rabbits with successful modeling were taken and divided into four groups of 10 each: blank control group: no administration; amlodipine administration group: amlodipine 0.28mg / kg administration; niacin administration group: administration of Niacin 110 mg / kg; the composition administration group (containing amlodipine and nicotinic acid): Amlodipine 0.28 mg / kg and nicotinic acid 110 mg / kg were given.

[0064] Administration method: the medicines of each dosage group were ground into fine powder 30 minutes be...

Embodiment 3

[0069] Example 3 The control effect of the composition on cardiac risk in mammals (including humans).

[0070] Grouping: Take 400 model animals (successfully modeled large squirrels) constructed in Example 1 and divide them into four groups, each with 100 animals. Each group continues to be given high-fat feed and continuous noise stimulation. Blank control group: no administration; Amlodipine administration group: give amlodipine 0.5mg / kg; Nicotinic acid administration group: give niacin 200mg / kg; This composition administration group (containing amlodipine and tobacco acid): give amlodipine 0.5mg / kg and niacin 200mg / kg.

[0071] Administration method: the medicines of each dosage group were ground into fine powder 30 minutes before the test in the morning of the same day, and made into a perfusion liquid with 3% starch paste (starch, produced by North China Pharmaceutical Factory), and 30 ml was perfused every day.

[0072] After feeding for 2 years, each group was executed...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a pharmaceutical composition of amlodipine or a pharmaceutically acceptable acid additive salt thereof and nicotinic acid, a medical box containing the compositions, and a method of using the compositions to treat patients suffering from angina pectoris, atherosclerosis and accompanied hypertension, and treating patients (including human beings) having heart risk symptoms. The invention also relates to an additive synergic composition of the amlodipine and the nicotinic acid, which can be used for treating the patients suffering from the angina pectoris, the atherosclerosis and the accompanied hypertension and the hyperlipoidemia, and treating the patients (including human beings) having heart risky symptoms.

Description

technical field [0001] The present invention relates to a pharmaceutical composition containing amlodipine or a pharmaceutically acceptable salt thereof and nicotinic acid, a kit containing these compositions, and using these compositions to treat patients with coronary heart disease, atherosclerosis, angina pectoris, combined high Patients with high blood pressure and hyperlipidemia and patients whose main symptoms are heart risk symptoms. Background technique [0002] Hypertension is one of the most common cardiovascular diseases that endanger human health. It is a major public health issue worldwide. A large number of evidence-based medical studies have confirmed that: as blood pressure increases, the risk of cardiovascular disease increases significantly. Blood pressure increases from 115 / Starting from 75mmHg, every increase of 20 / 10mmHg will double the cardiovascular risk, and active treatment can effectively reduce the morbidity and mortality of cardiovascular events,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/4422A61K31/455A61P9/10A61P9/12
Inventor 王雷波王海勇付俊昌
Owner BEIJING ROCK PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com