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Pharmaceutical composition and uses thereof

A composition and drug technology, applied in the directions of drug combination, pharmaceutical formula, plant raw material, etc., can solve the problem of not seeing the sedative and hypnotic effect of total nephrine saponins, etc.

Inactive Publication Date: 2011-06-29
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the applicant has not seen relevant reports about the sedative and hypnotic effects of total saponins of anemarrhena

Method used

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  • Pharmaceutical composition and uses thereof
  • Pharmaceutical composition and uses thereof
  • Pharmaceutical composition and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Preparation of compound total saponins of Suanzaoren and total saponins of Anemarrhena:

[0021] Grind 700g of Semen jujubee samples, pass through a 40-mesh sieve, fill the extracting kettle with Semen jujubee powder, add 95% ethanol whose mass is 20% of Semen jujubae powder, and obtain the optimal condition of supercritical extraction through orthogonal experiments: : The extraction experiment was carried out at an extraction temperature of 50° C. and an extraction pressure of 30 MPa. After the extraction was completed, the total saponins of the compound Suanzaoren extract were released from the bottom of the separation kettle. Extraction time 2.5h, CO 2 The flow rate was 21kg / h, and the extraction rate was 7.29%. The extracted solution was concentrated with a rotary evaporator, and the concentrated liquid was collected and dried at 70°C to obtain a sample of total saponins from jujube seed, which was placed in a desiccator for use.

[0022] Another 400g Anemarrhena s...

Embodiment 2

[0025] Study on the Prescription Ratio of Total Saponins of Jujube Seed and Total Saponins of Anemarrhena

[0026] Orthogonal experimental design was used to study the interaction and dose ratio of total saponins of Anemarrhena and total saponins of Suanzaoren by sedation experiment.

[0027] experimental design

[0028] The total saponins of Anemarrhena are factor B, and the total saponins of Suanzaoren are factor A, and three levels (200 mg·kg -1 , 80mg·kg -1 , 40mg·kg -1 ), and the interaction is expressed as A*B. Using a two-factor three-level orthogonal test, choose L 9 (3 4 ) orthogonal table, carry out 9 groups of experiments, the first group: A 1 B 1 , the second group: A 1 B 2 ;The third group: A 1 B 3 , the fourth group: A 2 B 1 ; fifth group A 2 B 2 , the sixth group: A 2 B 3 , the seventh group: A 3 B 1 , eighth group: A 3 B 2 , Group 9: A 3 B 3 . Repeat each group 5 times. The factor level table and orthogonal design are shown in Table 1 a...

Embodiment 3

[0042] Study on the sedative and hypnotic effects of compound jujube seed total saponins and total saponins of Anemarrhena and its disassembly

[0043] Sedation test (mouse spontaneous activity test)

[0044] Experimental design: According to the previous experiment, the dose of total saponins of Suanzaoren is A, and the dose of total saponins of Anemarrhena is B. The total saponins of Anemarrhena and total saponins of Suanzaoren are mixed at a ratio of 1:2, and the mixture is designed in three doses: large, medium and small. Level, respectively A: 266+B: 133mg·kg -1 , A: 132+B: 66mg·kg -1 , A: 66+B: 33mg·kg -1 . Plus the positive control and the blank control, there are 7 groups in total, that is, the total saponins of Anemarrhena, the total saponins of Suanzaoren, the compound high-dose group, the medium-dose group, the low-dose group, the positive control group and the blank control group. By comparing the effects of total timosaponins group and blank group, the sedativ...

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Abstract

The invention relates to a pharmaceutical composition, which mainly comprises wild jujube seed total saponin and anemarrhena total saponin with the mass ratio of between 0.5 to 1 and 4 to 1. Tests show that the pharmaceutical composition has better effects compared with single wild jujube seed total saponin or anemarrhena total saponin; and the invention also proves that the anemarrhena total saponin can also be used to prepare sedative hypnotic medicines.

Description

(1) Technical field [0001] The invention relates to a pharmaceutical composition, in particular to a compound total saponins of jujube seed and total saponins of anemarrhena, and its application for preparing sedative and hypnotic drugs. (2) Background technology [0002] Suanzaoren is sweet and acidic, and the acid enters the liver to benefit the liver and blood, and tonify the liver deficiency. If the liver blood is sufficient, the heart and blood will also be vigorous, and the heart will be peaceful and the mind will be at peace. Anemarrhena is bitter and cold, nourishes kidney yin, nourishes yin water to reduce heart fire. Suanzaoren and Anemarrhena, combined with sour and bitter, treats the heart and liver, nourishes the heart yin, nourishes the liver and blood, soothes the nerves and calms the mind, clears deficiency and heat, eliminates irritability and cures insomnia due to deficiency. It is a commonly used Chinese medicine for calming the mind and calming the nerve...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8964A61P25/20
Inventor 李乐
Owner ZHEJIANG UNIV OF TECH
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