Pharmaceutical composition for treating type 2 diabetes

A composition and diabetes technology, applied in the directions of drug combination, metabolic diseases, pharmaceutical formulations, etc., can solve problems such as changing and lowering triacylglycerol levels, reducing side effects, controlling the occurrence of diabetic complications, and disappearing thirst and hunger Effect

Inactive Publication Date: 2009-06-03
TIANJIN JINGUIGU XYLITOL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The clinical trials of pioglitazone also selected patients with abnormal lipids. Treatment with pioglitazone can reduce triacylglycerol levels and increase HDL-C, but there is no consistent change in LDL and TC

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Preparation of capsules:

[0022] By containing pioglitazone 10g, 5g xylitol, the pharmaceutical composition of taurine 60g, micropowder silica gel 5g, mix uniformly, 10% hydroxypropyl methylcellulose 80% ethanol liquid is used as binding agent, fluidized bed granulation package Clothes, put into No. 0 capsules, and make 1000 capsules.

Embodiment 2

[0024] Preparation of tablets:

[0025] Will contain pioglitazone 100g, 10g xylitol, the pharmaceutical composition of taurine 80g, add compressible starch 100g, dextrin 25g, microcrystalline cellulose 5g, magnesium stearate 2.5g, mix uniformly, 40% ethanol makes Granules, compressed into tablets, made into 1000 pieces, coated with film.

Embodiment 3

[0027] Preparation of oral solution:

[0028] A pharmaceutical composition containing 10 g of pioglitazone, 3 g of xylitol, 20 g of taurine, and 100 g of sorbitol are uniformly mixed, added with water to make 1000 ml, and bottled.

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PUM

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Abstract

The invention relates to a pharmaceutical composition containing pioglitazone, taurine and xylitol thereof. The pharmaceutical composition contains 10-100mg of the pioglitazone, 1-10g of the taurine, 1-10g of the xylitol thereof and a pharmaceutically acceptable carrier thereof. The composition can improve curative effect of single drug use and reduce dosage of antidiabetic drugs. Taking the composition can help relieve 'three-much' symptoms (much drinking, much eating and polyuria) of patients, substantially eliminate thirst and hunger, and reduce glucose in urine. After long-term use of the composition, the symptoms disappear, and diabetic complications are effectively controlled.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating diabetes, in particular to a pharmaceutical composition containing pioglitazone, taurine and xylitol. Background technique [0002] As the world enters an aging society in the 21st century, people's living standards improve and diet structure changes, the incidence of diabetes is increasing year by year, and it has become the third largest disease threatening human life and health after cardiovascular system and tumors. Nowadays, diabetes is no longer just a threat to the elderly, and the younger patients are becoming more and more obvious. According to an international study, diabetes will increase dramatically in China, India and some developing countries in Africa in the 21st century. The number of people with diabetes in China will be the first in the world. [0003] Diabetes is listed as the third largest "killer" after AIDS and cancer in the medical field, and is known as "sub-c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4439A61K47/10A61P3/10A61K31/185
Inventor 马永华邱洪江
Owner TIANJIN JINGUIGU XYLITOL
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