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Compound preparation of berberine hydrochloride

A technology of berberine hydrochloride and compound preparations, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, organic active ingredients, etc., and can solve the problems of poor stability and low solubility of preparations

Inactive Publication Date: 2009-07-01
ZHENGZHOU HOUYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the veterinary medicines containing berberine hydrochloride are mainly powder and berberine sulfate injection, which have low solubility and poor preparation stability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Take 3g of citric acid and 30ml of water for injection to dissolve by heating, add 20g of ethanol, add 5g of glycerol formal, add 2g of TW-80, stir well, add TMP, heat to dissolve, add 0.05g of butylpropyl inosine to dissolve, add hydrochloric acid The berberine is dissolved by heating, analgesics and antioxidants are added, and 100 ml of water for injection is supplemented to obtain the compound preparation of this example.

Embodiment 2

[0028] Take 3g of citric acid and 30ml of water for injection to dissolve by heating, add 20g of ethanol, add 15g of polyethylene glycol PEG400, add 2g of TW-80, stir evenly, add TMP, heat to dissolve, add 2.5g of enrofloxacin, heat to dissolve, add poly 0.1g of myocytes are heated to dissolve, add berberine hydrochloride to heat to dissolve, add analgesics and antioxidants, and add water for injection to 100ml to get it.

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PUM

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Abstract

The invention relates to a berberine hydrochloride compound preparation made from the following components in terms of weight percentage: 0.5-1% of berberine hydrochloride, 2-5% of antibacterial medicament, 0-0.1% of antiviral medicament, 1-1.5% of antibacterial synergist, 0-15% of stabilizer, 0-30% of cosolvent, 0-5% of local anodyne, 0-2% of antioxidant and balance of disperse medium. The inventive compound preparation has the following advantages: (1) the compound preparation solves the instability problem of berberine injection by making the berberine into orally taken liquid; (2) the berberine hydrochloride when used with enrofloxacin and TMP together can be used as the preferable medicament for intestinal infections, is more advantageous in treating intestinal infections caused by escherichia coli and salmonella than other single antibiotics sold in the market, especially good for drug resistant strains, is applied two times a day for three constant days, and prevention and treatment rate is up to 100%; (3) the berberine hydrochloride when used with enrofloxacin, gentamicin sulphate and TMP together is used to treat septicaemia, respiratory tract infections and intestinal infections caused by sensitive bacteria.

Description

Technical field [0001] The invention relates to a compound preparation of berberine hydrochloride, which belongs to a compound preparation of Chinese and Western veterinary medicine. Background technique [0002] Berberine hydrochloride is extracted and refined from the traditional Chinese medicine Phellodendron chinense, Coptis, Sankezhen, and other plants. It can also be an artificially synthesized alkaloid. Its main functions are to clear away heat and dampness, purify fire and detoxify, clear intestines and relieve diarrhea; modern pharmacological research has broad-spectrum antibacterial effects: inhibit bacteria, fungi, viruses, and antiprotozoa. Berberine hydrochloride has a strong inhibitory effect on hemolytic streptococcus, meningococcus, pneumonia, Vibrio cholerae and Staphylococcus aureus. It has the strongest effect on dysentery and Clostridium tuberculosis; it is mainly used to prevent and treat animal infections. Avian pullorum, typhoid fever, Escherichia coli, cho...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61K45/06A61P31/00
CPCY02A50/30
Inventor 吴红云李建正卜昌超
Owner ZHENGZHOU HOUYI PHARMA
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