Alkannin microemulsion composition

Abstract

The invention discloses a microemulsion composition containing alkannin, which comprises alkannin or alkannin ramification, emulsifier, assistant emulsifier, oil and water. The composition can greatly improve the solubility of the alkannin.

Description

technical field [0001] The invention relates to a shikonin microemulsion composition capable of significantly increasing the solubility of shikonin. Background technique [0002] Shikonin is one of the main components extracted from the root of the perennial herbaceous plant Comfrey, which has hemostatic, anti-inflammatory, antibacterial, antiviral and anticancer pharmacological activities. Its chemical structure is naphthoquinone, optically active, purple-red needle-like crystal with metallic luster, slightly soluble in water, easily soluble in benzene, ethanol, ether and other organic solvents. The poor water solubility of shikonin limits the effective development and utilization of its formulations. [0003] The Chinese patent announcement number is CN 1399957A, which discloses the application of shikonin and its derivatives in pharmaceuticals, which have therapeutic effects on human microbial infection, inflammation, tumor, hemorrhage, blood disease and immune regulatio...

AI Technical Summary

Problems solved by technology

But, the deficiency of this method is, not according to the property that shikonin and its derivatives are insoluble in water, easily soluble in oil, alcohol, ethers, provide a method for the administration mode of disclosed shikonin and its derivatives. A way to increase solubility for formulation needs

[0004] Chinese patent notification number CN1634001A discloses a method for improving the solubility of shikonin by preparing shikonin nanoparticles by using nanotechnology. However, the defect of this method is that acetone, an organic solvent with certain toxicity, is used.