Alkannin microemulsion composition
A technology of microemulsion and shikonin, applied in the directions of drug combination, anti-inflammatory agent, antiviral agent, etc., can solve the problems of increasing solubility and use, and achieve the effect of increasing solubility
Inactive Publication Date: 2009-07-08
石河子大学医学院第一附属医院
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- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
But, the deficiency of this method is, not according to the property that shikonin and its derivatives are insoluble in water, easily soluble in oil, alcohol, ethers, provide a method for the administration mode of disclosed shikonin and its derivatives. A way to increase solubility for...
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0012] Shikonin: 0.1 parts, polyoxyethylene castor oil: 10 parts, ethanol: 10 parts, isopropyl myristate: 10 parts, water: 30 parts
Embodiment 2
[0014] Acetylshikonin: 0.1 parts, polyoxyethylene hydrogenated ethylene castor oil: 10 parts, propylene glycol: 5 parts, oleic acid: 10 parts, water: 20 parts
Embodiment 3
[0016] Shikonin: 0.3 parts, Poloxamer-188: 10 parts, Ethanol: 5 parts, Isopropyl palmitate: 10 parts, Water: 10 parts
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The invention discloses a microemulsion composition containing alkannin, which comprises alkannin or alkannin ramification, emulsifier, assistant emulsifier, oil and water. The composition can greatly improve the solubility of the alkannin.
Description
technical field [0001] The invention relates to a shikonin microemulsion composition capable of significantly increasing the solubility of shikonin. Background technique [0002] Shikonin is one of the main components extracted from the root of the perennial herbaceous plant Comfrey, which has hemostatic, anti-inflammatory, antibacterial, antiviral and anticancer pharmacological activities. Its chemical structure is naphthoquinone, optically active, purple-red needle-like crystal with metallic luster, slightly soluble in water, easily soluble in benzene, ethanol, ether and other organic solvents. The poor water solubility of shikonin limits the effective development and utilization of its formulations. [0003] The Chinese patent announcement number is CN 1399957A, which discloses the application of shikonin and its derivatives in pharmaceuticals, which have therapeutic effects on human microbial infection, inflammation, tumor, hemorrhage, blood disease and immune regulatio...
Claims
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Patent Timeline
Login to view more IPC IPC(8): A61K9/107A61K31/122A61K47/34A61K47/14A61P7/04A61P31/04A61P29/00A61P31/12A61P35/00A61K47/10A61K47/24A61K47/26A61K47/44
Inventor 王新春陈文韩博连文远李悦江发寿张华蒲宇红
Owner 石河子大学医学院第一附属医院
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