Method of preparing honeysuckle extract by applying membrane filtration technology

A technology of honeysuckle extract and filtration technology, which is applied in the field of traditional Chinese medicine preparation, can solve the problems of poor preparation process stability, high process cost, and low transfer rate of chlorogenic acid, so as to improve medicinal value, reduce allergenic components, and save medicinal materials cost effect

Inactive Publication Date: 2009-09-16
NAT ENG RES CENT FOR TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a method for preparing honeysuckle extract by applying membrane filtration technology, which is used to solve technical problems such as low chlorogenic acid transfer rate, high process cost, and poor preparation process stability in the current honeysuckle extraction process. The invention is realized through the following technical solutions:

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Weigh 200g of honeysuckle, add 12 times of water and 2400ml of water and decoct (95°C) for 1.5 hours, filter, add 10 times of water and 2000ml of water and decoct (95°C) for 1.0 hour, filter, combine the filtrate, divide into two parts, One part is separated by membrane filtration, and the other part is separated by alcohol precipitation.

[0019] 1. Membrane filtration and separation: take the extract, concentrate under reduced pressure at 60°C to a specific gravity of 1.05 (60°C), centrifuge at a speed of 4500 rpm for 15 minutes, take the supernatant, pass through a microfiltration membrane (0.65Micron), and control the flow rate 10ml / min, washed and filtered with distilled water 3 times, 100ml each time; the microfiltrate was passed through an ultrafiltration membrane (10000NMWC), the control flow rate was 5ml / min, washed and filtered with distilled water 3 times, 50ml each time, the ultrafiltrate was reduced to 60°C Concentrate under reduced pressure to a specific g...

Embodiment 2

[0032] Weigh 200g of honeysuckle, add 8 times of water and 1600ml of water and decoct (95°C) for 1 hour, filter, add 6 times of water and 1200ml of water and decoct (95°C) for 0.5 hours, filter, combine the filtrates, and put the filtrate at 60°C Concentrate under reduced pressure to a specific gravity of 1.05 (60°C), centrifuge at a speed of 4000 rpm for 20 minutes, take the supernatant, pass it through a microfiltration membrane (0.42 Micron), control the flow rate at 5ml / min, wash and filter with distilled water twice, each 100ml each time; the microfiltrate is passed through an ultrafiltration membrane (1000NMWC), the flow rate is controlled at 1ml / min, washed and filtered twice with distilled water, 50ml each time, the ultrafiltrate is concentrated under reduced pressure at 60°C to a specific gravity of 1.2 (60°C), vacuum Dry to obtain dry powder of honeysuckle extract.

Embodiment 3

[0034] Weigh 200g of honeysuckle, add 18 times of water and 3600ml of water and decoct (95°C) for 2 hours, filter, add 12 times of water and 2400ml of water and decoct (95°C) for 0.8 hours, filter, combine the filtrates, and put the filtrate at 60°C Concentrate under reduced pressure to a specific gravity of 1.0 (60°C), centrifuge at a speed of 5000 rpm for 15 minutes, take the supernatant, pass through a microfiltration membrane (0.5 Micron), control the flow rate at 7ml / min, and wash and filter with distilled water 5 times, each 100ml each time; the microfiltrate is passed through an ultrafiltration membrane (30000NMWC), the flow rate is controlled at 3ml / min, washed and filtered with distilled water 5 times, 50ml each time, the ultrafiltrate is concentrated under reduced pressure at 60°C to a specific gravity of 1.2 (60°C), vacuum Dry to obtain dry powder of honeysuckle extract.

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PUM

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Abstract

The invention provides a method of preparing a honeysuckle extract by applying membrane filtration technology, comprising the steps of: firstly extracting the honeysuckle by adding water and decoction; implementing decompression, concentration and centrifugation; removing most of impurities with a micro-filtration membrane; and further implementing refining with an ultra-filtration membrane. Compared with the prior art, the method not only can guarantee the extraction of the effective components of honeysuckle, but also can reduce the leaching of impurities, can effectively remove the impurities, reduce the sensitized components and improve the total content of the effective components. Therefore, the method can overcome the shortcomings of the prior art, has simple operation and high recovery rate of separated materials, and can also provide process conditions which are more conducive to the industrial production.

Description

technical field [0001] The invention relates to a method for preparing traditional Chinese medicine, in particular to a method for extracting and purifying active ingredients of traditional Chinese medicine, and in particular to a method for preparing honeysuckle extract by applying membrane filtration technology. Background technique [0002] Lonicera japonica Thunb., Lonicera hypoglauca Miq., Lonicera confuse DC. or Lonicera dasytyla Rehd. are the dry flower buds or the first flowers of Lonicera dasytyla Rehd. Honeysuckle is a commonly used traditional Chinese medicine. It is cold in nature and sweet in taste. It has significant heat-clearing and detoxifying, anti-bacterial, anti-inflammatory and anti-viral effects. fever. [0003] The organic acid components represented by chlorogenic acid contained in honeysuckle are its main active ingredients. At present, the method for extracting organic acid components from honeysuckle usually adopts warm soaking method, boiling me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/355A61P31/04A61P31/12A61P11/04A61P17/02A61K133/00
Inventor 刘志远路钧镧丁洁王茜张继全
Owner NAT ENG RES CENT FOR TRADITIONAL CHINESE MEDICINE
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