Tumor cell actively targeted drug delivery system, preparation method and application thereof

A drug-loading system and tumor cell technology, which is applied in the field of drug-loading systems actively targeting tumor cells, can solve problems such as toxic and side effects, and achieve the effects of good biocompatibility, easy implementation, and simple preparation methods

Inactive Publication Date: 2009-09-23
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although increasing the dose can meet this requirement, with the increase of the dose of the drug, it will cause serious side effects due to the non-selectivity of the drug while the curative effect is improved.

Method used

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  • Tumor cell actively targeted drug delivery system, preparation method and application thereof
  • Tumor cell actively targeted drug delivery system, preparation method and application thereof
  • Tumor cell actively targeted drug delivery system, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1. Drug delivery system for active targeting of tumor cells

[0032] In parts by weight, the composition and active ingredient content of the drug loading system are: 5 parts of vincristine, 100 parts of bovine serum albumin, 200 parts of folic acid, 0.05 part of 25% glutaraldehyde, 0.005 part of ethanol, anhydrous di 5 parts of methyl sulfoxide, 80 parts of dicyclohexyl carbodiimide, 70 parts of N-hydroxysuccinimide and 0.4 parts of triethylamine, 100 parts of anhydrous acetone, 100 parts of ether, polybutylene succinate 50 parts of ester.

Embodiment 2

[0033] Example 2. Drug delivery system for active targeting of tumor cells

[0034]In parts by weight, the composition and active ingredient content of the drug loading system are: 10 parts of vincristine, 200 parts of bovine serum albumin, 400 parts of folic acid, 0.1 part of 25% glutaraldehyde, 0.01 part of ethanol, anhydrous di 15 parts of methyl sulfoxide, 100 parts of dicyclohexyl carbodiimide, 70 parts of N-hydroxysuccinimide and 0.6 parts of triethylamine, 200 parts of anhydrous acetone, 200 parts of ether, polybutylene succinate 100 parts of ester.

Embodiment 3

[0035] Example 3. Drug delivery system for active targeting of tumor cells

[0036] In parts by weight, the composition and active ingredient content of the drug loading system are: 0 part of vincristine, 150 parts of bovine serum albumin, 300 parts of folic acid, 0.07 part of 25% glutaraldehyde, 0.007 part of ethanol, anhydrous di 10 parts of methyl sulfoxide, 90 parts of dicyclohexyl carbodiimide, 70 parts of N-hydroxysuccinimide and 0.5 parts of triethylamine, 150 parts of anhydrous acetone, 150 parts of ether, polybutylene succinate 75 parts of ester.

[0037] After testing, the drug-loading systems provided in the above examples all meet the requirements of the instructions, and the effect of Example 2 is better.

[0038] 2. Preparation of colloidal suspension for active targeting of cells

[0039] Weigh 200-400 parts of folic acid, dissolve in 5-15 parts of anhydrous dimethyl sulfoxide (DMSO), then add 80-100 parts of dicyclohexylcarbodiimide (DCC) and 70-80 parts of N...

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PUM

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Abstract

The invention discloses a tumor cell actively targeted drug delivery system. The drug delivery system comprises the following component contents (by weight): 100-200 parts of bovine serum albumin, 200-400 parts of folic acid, 0.05-0.10 part of 25% glutaral pentanedial, 0.005-0.01 part of alcohol, 5-15 parts of anhydrous dimethyl sulphoxide, 80-100 parts of dicyclohexylcarbodiimide, 70-80 parts of N-hydroxysuccinimide, 0.4-0.6 part of tri-ethylamine, 100-200 parts of anhydrous acetone, 100-200 parts of ether, and 50-100 parts of polybutylene succinate. The drug delivery system comprises preparation steps of activated folate ester, folic acid-bovine serum albumin and colloid suspension. The drug delivery system has low toxicity to normal tissues while killing tumor cells with high-expression of folate receptors; and the folic acid has low immunogenicity, convenient modification and simple storage. The drug delivery system has the advantages of needing short time to reach targets and clearing blood quickly; has obvious advantages in tumor chemotherapy. The invention further discloses a preparation method and application of the tumor cell actively targeted drug delivery system.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a drug-carrying system actively targeting tumor cells, a preparation method of the drug-carrying system, and development and application of anti-tumor drugs of the drug-carrying system. Background technique [0002] The incidence of tumor (cancer) is constantly increasing, and has become a common disease that seriously endangers human health. Chemotherapy, as one of the important means of tumor treatment, has an irreplaceable position in the treatment of malignant tumors with surgery and radiotherapy. However, the existing anti-tumor drugs have low selectivity. They not only kill tumor cells, but also may damage certain types of normal cells in the body. Therefore, obvious toxic reactions often occur during treatment, which affects the curative effect. Chemotherapy drugs have been recognized as effective preparations for treating tumors, but in order to effectively kill tumor cells, a c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/42A61K47/48A61K9/10A61K31/475A61P35/00A61K47/64
Inventor 楼一层颜香凤虎征宇杨翰阮班昭黄芬易辉周园胡佳兴
Owner WUHAN UNIV OF TECH
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