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Method for testing quality of reineckea carnea medicinal materials

A quality inspection method and technology of herbal materials, which are used in pharmaceutical formulations, antipyretics, material separation, etc.

Inactive Publication Date: 2009-10-07
GUIZHOU NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, there have been reports on the chemical constituents of Auspicious Grass at home and abroad, but there are few reports on the research literature on the quality standards of Auspicious Grass. A TLC identification study was carried out as a control, and a TLC identification study report on its chloroform extraction site was also reported

Method used

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  • Method for testing quality of reineckea carnea medicinal materials
  • Method for testing quality of reineckea carnea medicinal materials
  • Method for testing quality of reineckea carnea medicinal materials

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0102] Embodiment 1 of the present invention: the quality detection method of auspicious herbal medicinal material comprises the following items:

[0103] Characters: Dried whole grass is yellowish brown, with slender rhizomes and obvious nodes, with residual membranous scale leaves on the nodes, and a few curved and curled fibrous roots, with shriveled leaves.

[0104] Identification: (1) Grind Auspicious Grass into a coarse powder, take 2g of medicinal material powder, add 60mL of methanol to water bath and reflux twice, each time for 1h, filter, combine the filtrate, concentrate to nearly dry, dissolve in 40mL of water, add 0.3g of activated carbon , heated, filtered, and the filtrate was transferred to a separatory funnel, then extracted 3 times with water-saturated n-butanol, 20ml each time, and the n-butanol extract was divided, the solvent was evaporated, and the residue was dissolved in 3mL of methanol as the test solution. Sample solution; Accurately weigh an appropri...

Embodiment 2

[0111] Embodiment 2 of the present invention: the quality detection method of auspicious herbal medicinal materials can only contain the following items:

[0112] Identification: Grind Auspicious Grass into coarse powder, take 2g of medicinal material powder, add 50mL of methanol and reflux in a water bath for 3 times, each time for 0.5h, filter, combine the filtrate, concentrate to nearly dry, dissolve in 30mL of water, add 0.5g of activated carbon, heat , filtered, the filtrate was transferred to a separatory funnel, and then extracted twice with water-saturated n-butanol, 25ml each time, the n-butanol extract was divided, the solvent was evaporated, and the residue was dissolved in 4mL of methanol as the test solution Accurately weigh an appropriate amount of kaitigenin reference substance, add methanol to make a solution containing 0.5mg per 1mL, as the reference substance solution; according to the Chinese Pharmacopoeia, Appendix VI B thin-layer chromatography experiment, ...

Embodiment 3

[0118] Embodiment 3 of the present invention: the quality detection method of auspicious herbal medicine can only contain the following items:

[0119] Identification: Grind Auspicious Grass into coarse powder, take 2g of medicinal material powder, add 50mL of methanol to water bath and reflux 3 times, each time for 0.5h, filter, combine the filtrates, concentrate to nearly dry, dissolve with 30mL of water, transfer to a separatory funnel, Extract with petroleum ether 4 times, 15mL each for the 1st and 2nd times, 10mL for the 3rd and 4th times, discard the petroleum ether liquid, then extract 2 times with n-butanol saturated with water, 15ml each time, and extract n-butanol separately solution, evaporated the solvent, and dissolved the residue in 2mL of methanol as the test solution; accurately weighed an appropriate amount of the extracted 5-O-β-D-glucopyranoside reference substance, added methanol to make a solution containing 0.5mg per 1mL , as the reference substance solut...

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Abstract

The invention discloses a method for testing quality of reineckea carnea medicinal materials, which includes part or whole of description, identification, examination and content measurement. The aforementioned is indicated as a thin-layer chromatography identification of kitigenin and / or kitigenin 5-O-beta-D-glucopyranose saponin, the content measuring is indicated as measuring the content of saponin in medicinal materials with the method of ultraviolet spectrophotometry. Compared to the existing technology, the invention brings forward a reineckea carnea thin-layer chromatography identification process and total saponin content measuring process with taking kitigenin and kitigenin 5-O-beta-D-glucopyranose saponin as reference substance, which perfects the quality detecting standard of reineckea carnea medicinal materials, recuperates the deficiency of the existing quality detecting technology, makes this quality detecting technology more scientific and reasonable, and ensures its security and validity in clinical application.

Description

Technical field: [0001] The invention relates to a quality detection method of auspicious herbal medicinal materials, belonging to the technical field of quality control of medicinal materials. Background technique: [0002] Most of the traditional Chinese medicines and their preparations in my country lack strict quality standards and scientific testing methods, so it is difficult to effectively control their internal quality, cannot guarantee the safety and effectiveness of medication, and do not meet the requirements of the international pharmaceutical market, which seriously restricts the Chinese medicine industry in my country. development of. Strengthening the research on the quality control of traditional Chinese medicinal materials is a key issue in the standardization and standardization of traditional Chinese medicine. Only by carrying out scientific quality control on Chinese herbal medicines can the quality of Chinese medicine be guaranteed and the "safety, effec...

Claims

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Application Information

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IPC IPC(8): A61K36/896G01N30/90G01N21/33A61P11/00A61P11/06A61P19/02A61P19/08A61P29/00A61P31/06
Inventor 陈华国周欣周婵媛刘海
Owner GUIZHOU NORMAL UNIVERSITY
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