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Radioimmunotherapy and imaging of tumor cells that express viral antigens

A virus antigen, tumor cell technology, applied in anti-tumor drugs, radioactive preparations in vivo, gene therapy, etc., can solve toxicity and other problems

Inactive Publication Date: 2009-11-11
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently existing cancer radioimmunotherapy utilizes tumor-associated antigens which are "self" antigens in the patient's body, which results in significant uptake of antibodies in normal organs, which can lead to toxicity
One of the challenges with immunotherapy is the identification of tumor-specific antigens that can exert effects while limiting damage to normal tissues

Method used

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  • Radioimmunotherapy and imaging of tumor cells that express viral antigens
  • Radioimmunotherapy and imaging of tumor cells that express viral antigens
  • Radioimmunotherapy and imaging of tumor cells that express viral antigens

Examples

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Embodiment 2

[0118] Prophetic Example 2. Indirect labeling of antibodies and F(ab)' using succinimidyl-HYNIC (hydrazinyl nicotinamide) 2 Fragments: For "indirect" radiolabeling with e.g. 188-Re and 111-In, antibodies and F(ab') 2 Fragments can be derivatized, eg, with succinimidyl-HYNIC (hydrazinonicotinamide), and purified as in Blankenberg et al. (J. Nucl. Med. 40:184-191, 1999). An advantage of using "indirect" labeling via bifunctional chelators such as HYNIC or other substances over "direct" labeling is that the radiolabeling process is greatly simplified and shortened by using aliquots of HYNIC-binding molecules that Binding molecules can be stored frozen for extended periods of time. Incorporation of HYNIC into proteins can be monitored spectrophotometrically at 385 nm (King et al. (1986) Biochem. 25:5774-5779). The initial HYNIC to protein ratio is preferably chosen such that the final HYNIC to protein ratio does not exceed about 1.5, since above this number partial loss of immu...

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Abstract

Methods and compositions are provided for treating and imaging a virus-associated cancer, where the methods comprise administering to a subject a radiolabeled binding molecule, wherein the binding molecule binds to a virus antigen expressed by virus-associated cancer cells in the subject.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Patent Application No. 60 / 876,052, filed December 19, 2006, the contents of which are incorporated herein by reference. [0003] statement of government support [0004] The invention disclosed herein was made with United States Government support under Grant Nos. AI60507, AI33774, AI33142, AI52733, HL59842, U54 AI157158, CA078527, and AI51519 awarded by the National Institutes of Health. Accordingly, the US Government has certain rights in this invention. field of invention [0005] The present invention relates to radioimmunological methods for treating and imaging tumor cells expressing viral antigens with antiviral antigen binding molecules, such as antibodies, having radioisotopes. Background of the invention [0006] Radioimmunotherapy (RIT) was developed nearly 30 years ago to treat cancer. The first clinical trial for hepatoma at RIT in the United States ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K48/00
CPCA61K51/1006A61P35/00A61P35/02Y02A50/30
Inventor E·达达乔瓦A·卡萨德瓦尔H·斯特里克勒R·D·伯克
Owner ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV
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